Increased pentosidine, an advanced glycation end product, in serum and synovial fluid from patients with knee osteoarthritis and its relation with cartilage oligomeric matrix protein
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
15897309
PubMed Central
PMC1755507
DOI
10.1136/ard.2004.029140
PII: S0003-4967(24)42979-8
Knihovny.cz E-resources
- MeSH
- Arginine analogs & derivatives analysis blood MeSH
- Osteoarthritis, Knee blood diagnostic imaging metabolism MeSH
- Biomarkers analysis blood MeSH
- Cartilage Oligomeric Matrix Protein MeSH
- Extracellular Matrix Proteins analysis MeSH
- Glycoproteins analysis MeSH
- Cartilage, Articular chemistry MeSH
- Middle Aged MeSH
- Humans MeSH
- Lysine analogs & derivatives analysis blood MeSH
- Matrilin Proteins MeSH
- Cross-Sectional Studies MeSH
- Radiography MeSH
- Aged MeSH
- Severity of Illness Index MeSH
- Synovial Fluid chemistry MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Arginine MeSH
- Biomarkers MeSH
- Cartilage Oligomeric Matrix Protein MeSH
- Extracellular Matrix Proteins MeSH
- Glycoproteins MeSH
- Lysine MeSH
- Matrilin Proteins MeSH
- pentosidine MeSH Browser
- TSP5 protein, human MeSH Browser
BACKGROUND: Pentosidine, an advanced glycation end product, increasingly accumulates in articular cartilage with age, and contributes to the pathogenesis of osteoarthritis (OA). Increased pentosidine concentrations are associated with inflammatory disorders-for example, rheumatoid arthritis. OBJECTIVE: To compare pentosidine serum concentrations in patients with knee OA and in healthy volunteers and to determine a relationship between pentosidine and cartilage oligomeric matrix protein (COMP)-a marker of articular cartilage destruction. METHODS: Paired serum and synovial fluid samples were obtained by arthrocentesis from 38 patients with knee OA and from 38 healthy volunteers. Pentosidine concentration was measured by reverse phase high performance liquid chromatography with fluorescent detection and COMP was determined by sandwich ELISA. RESULTS: Significantly increased serum pentosidine (p<0.01) and COMP (p<0.05) levels were detected in the patients with OA compared with the control group. Serum pentosidine correlated significantly with synovial fluid pentosidine (p<0.001). Pentosidine in synovial fluid (p<0.05) and in serum (p<0.05) correlated significantly with synovial fluid COMP. Pentosidine and COMP concentrations did not correlate significantly with the radiological stage of the disease. CONCLUSION: Increased pentosidine serum concentration in patients with OA and its correlation with the cartilage destruction marker COMP in synovial fluid suggests that pentosidine may be important in OA pathology and is a new potential OA marker.
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