Intratracheal and intranasal immunization with ovalbumin conjugated with Bacillus firmus as a carrier in mice
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
16295664
DOI
10.1007/bf02931573
Knihovny.cz E-resources
- MeSH
- Lymphocyte Activation MeSH
- Antigens administration & dosage MeSH
- Administration, Intranasal MeSH
- Bacillus immunology MeSH
- Immunization MeSH
- Immunoglobulin G biosynthesis blood MeSH
- Mice, Inbred BALB C MeSH
- Mice MeSH
- Drug Carriers MeSH
- Ovalbumin administration & dosage immunology MeSH
- Antibodies, Bacterial biosynthesis blood MeSH
- Immunity, Mucosal MeSH
- In Vitro Techniques MeSH
- Th1 Cells immunology MeSH
- Trachea MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antigens MeSH
- Immunoglobulin G MeSH
- Drug Carriers MeSH
- Ovalbumin MeSH
- Antibodies, Bacterial MeSH
Inactivated Bacillus firmus (BF), G+ nonpathogenic bacterium of the external environment, was coupled to ovalbumin (OVA) and used in immunization experiments as antigen carrier. Balb/c mice were immunized thrice intra-tracheally and intra-nasally with conjugates of OVA and BF. Surprisingly, administration of OVA-BF conjugates inhibited anti-OVA IgG response in both sera and mucosal secretions if compared to an exposure to OVA alone. The suppression of antigen-specific antibody production was accompanied by promotion of TH1 phenotype.
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