Synthesis of a novel series of bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Acetylcholinesterase metabolism MeSH
- Enzyme Activation drug effects MeSH
- Cholinesterase Inhibitors pharmacology MeSH
- Chlorpyrifos pharmacology MeSH
- Rats MeSH
- Molecular Structure MeSH
- Oximes chemistry MeSH
- Pyridinium Compounds chemical synthesis chemistry pharmacology MeSH
- Cross-Linking Reagents chemistry MeSH
- Structure-Activity Relationship MeSH
- Xylenes chemistry MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Acetylcholinesterase MeSH
- Cholinesterase Inhibitors MeSH
- Chlorpyrifos MeSH
- Oximes MeSH
- Pyridinium Compounds MeSH
- Cross-Linking Reagents MeSH
- Xylenes MeSH
Nine potential AChE reactivators were synthesized using a modification of currently known synthetic pathways. Their potency to reactivate AChE inhibited by insecticide chlorpyrifos was tested in vitro. 2,2'-Bis(hydroxyiminomethyl)-1,1'-(1,4-phenylenedimethyl)-bispyridinium dibromide seems to be the most potent AChE reactivator. The reactivation potency of these compounds depends on structural factors such as length of the linking chain between both pyridinium rings and position of the oxime moiety on the pyridinium ring.
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