Macroporous hydrogels based on 2-hydroxyethyl methacrylate. Part 5: hydrolytically degradable materials
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Biocompatible Materials metabolism therapeutic use MeSH
- Hydrogels metabolism therapeutic use MeSH
- Hydrolysis MeSH
- Rats MeSH
- Methacrylates metabolism therapeutic use MeSH
- Spinal Cord Diseases pathology therapy MeSH
- Porosity MeSH
- Rats, Wistar MeSH
- Materials Testing methods MeSH
- Absorbable Implants * MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biocompatible Materials MeSH
- Hydrogels MeSH
- hydroxyethyl methacrylate MeSH Browser
- Methacrylates MeSH
Macroporous hydrogels based on 2-hydroxyethyl methacrylate, 2-ethoxyethyl methacrylate and N-(2-hydroxypropyl)methacrylamide, methacrylic acid and [2-(methacryloyloxy)ethyl]trimethylammonium chloride crosslinked with N,O-dimethacryloylhydroxylamine were prepared. Hydrogels were degraded in a buffer of pH 7.4. Completely water-soluble polymers were obtained over time periods ranging from 2 to 40 days. The process of degradation was followed gravimetrically and by optical and electron microscopy. In vivo biological tests with hydrogels based on copolymers of 2-ethoxyethyl methacrylate/N-(2-hydroxypropyl)methacrylamide were performed.
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