WWOX, a new potential tumor suppressor gene
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
17690733
DOI
10.5507/bp.2007.002
Knihovny.cz E-resources
- MeSH
- Gene Expression MeSH
- Humans MeSH
- Tumor Suppressor Proteins genetics MeSH
- Prostatic Neoplasms genetics MeSH
- Breast Neoplasms genetics MeSH
- Ovarian Neoplasms genetics MeSH
- Neoplasms genetics MeSH
- WW Domain-Containing Oxidoreductase MeSH
- Oxidoreductases genetics MeSH
- Genes, Tumor Suppressor * MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Tumor Suppressor Proteins MeSH
- WW Domain-Containing Oxidoreductase MeSH
- Oxidoreductases MeSH
- WWOX protein, human MeSH Browser
BACKGROUND: WWOX (WW domain-containing oxidoreductase) gene, located on chromosome 16q 23.3-24.1 in the region recognized as the common fragile site FRA16D is considered to be a tumor suppressor gene involved in various cancers: breast, ovarian, prostate, esophageal, lung, pancreatic, gastric and hepatic. The aim of this study was to describe (i) putative protein interactions of WWOX (ii) the molecular mechanisms of tumor suppressor activity (iii) present an overview of WWOX in relation to nervous system and breast, prostate and ovarian cancers. METHODS AND RESULTS: WWOX expression is up-regulated in endocrine organs indicating its importance in these tissues. In many cancers WWOX expression is down-regulated and low WWOX expression is related to poor prognosis. CONCLUSION: All the evidence suggest that WWOX can be considered as a new tumor suppressor gene and target for gene therapy due to the association of high WWOX expression with improved disease free survival.
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