Molecular epidemiology of PER-1 extended spectrum beta-lactamase among gram-negative bacteria isolated at a tertiary care hospital
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
18298053
DOI
10.1007/bf02932116
Knihovny.cz E-resources
- MeSH
- Acinetobacter baumannii drug effects enzymology genetics isolation & purification MeSH
- Anti-Bacterial Agents pharmacology MeSH
- beta-Lactamases genetics MeSH
- beta-Lactam Resistance drug effects genetics MeSH
- Ceftazidime pharmacology MeSH
- DNA Fingerprinting MeSH
- Acinetobacter Infections epidemiology transmission MeSH
- Integrons MeSH
- Humans MeSH
- Microbial Sensitivity Tests MeSH
- Multigene Family MeSH
- Hospitals, University MeSH
- Polymerase Chain Reaction methods MeSH
- Gene Transfer, Horizontal MeSH
- Pseudomonas Infections epidemiology transmission MeSH
- Pseudomonas aeruginosa drug effects enzymology genetics isolation & purification MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Turkey epidemiology MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- beta-lactamase PER-1 MeSH Browser
- beta-Lactamases MeSH
- Ceftazidime MeSH
The bla(PER-1) presence was sought by PCR in 289 ceftazidime resistant Gram-negative bacteria isolated at Dokuz Eylul University Hospital (Turkey) between 1998 and 2003. PER-1 production rates were 32.3, 33.9, 14.9 and 37.9% in the 1998-2000 period, 2001, 2002 and 2003, respectively. bla(PER-1) was detected in 46.2 and 35.9% of ceftazidime-resistant Pseudomonas aeruginosa and Acinetobacter baumannii isolates, respectively. ERIC-PCR results revealed that dissemination of two endemic clones for both P. aeruginosa (X and Y) and A. baumannii (A and B) was responsible for the high prevalence. Results of the conjugation tests and plasmid curing experiments suggested that bla(PER-1) was located on the chromosome in the representative strains. It was also shown for the first time that bla(PER-1) in a clinical isolate was associated with class-1 integron which could facilitate dissemination of bla(PER-1) among bacteria.
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