Detection of cefotaxime-resistant CTX-M-3 in clinical isolates of Serratia marcescens

. 2004 ; 49 (4) : 452-6.

Jazyk angličtina Země Spojené státy americké Médium print

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/pmid15530012

Strains of Serratia marcescens (isolated in a hospital during April and August 2000) resistant to ampicillin, chloramphenicol, trimethoprim-sulfamethoxazole, streptomycin, tetracycline, and gentamicin were characterized. Out of a total of 34 clinical isolates 6 (17.6 %) exhibited the extended spectrum beta-lactamases (ESBL) resistance; they were also resistant to cefotaxime (minimum inhibitory concentration, MIC > or = 128 microg/mL) but susceptible to imipenem (MIC < or = 0.5 microg/mL). This multidrug resistance was shown to be transferred by a conjugative plasmid. Transconjugants revealed similar MIC profiles when compared to the parental strains. Isoelectric focusing revealed one major transferable beta-lactamase (pI 8.4) which was further identified as CTX-M-3 by PCR and gene sequencing. The presence of strains with this type of ESBL showed the evolution of bla genes and their dissemination among at least three species of the family Enterobacteriaceae isolated within a single hospital. The predominance of CTX-M type enzymes found in this area of Taiwan appeared to be similar to that described in Poland.

Zobrazit více v PubMed

Antimicrob Agents Chemother. 2002 Jan;46(1):151-9 PubMed

J Microbiol Immunol Infect. 1998 Sep;31(3):171-9 PubMed

J Antimicrob Chemother. 1999 Oct;44(4):489-99 PubMed

Folia Microbiol (Praha). 2003;48(2):243-7 PubMed

Folia Microbiol (Praha). 2003;48(6):823-8 PubMed

Diagn Microbiol Infect Dis. 2003 Apr;45(4):221-4 PubMed

Int J Antimicrob Agents. 2003 May;21(5):497-9 PubMed

Int J Antimicrob Agents. 2000 Mar;14(2):137-42 PubMed

J Gen Microbiol. 1975 May;88(1):169-78 PubMed

Antimicrob Agents Chemother. 2003 Sep;47(9):2864-7 PubMed

Antimicrob Agents Chemother. 1998 Apr;42(4):827-32 PubMed

Mol Microbiol. 1989 Dec;3(12):1669-83 PubMed

Antimicrob Agents Chemother. 1990 May;34(5):858-62 PubMed

J Clin Microbiol. 2003 May;41(5):1912-8 PubMed

J Clin Microbiol. 2003 Aug;41(8):3933-5 PubMed

Antimicrob Agents Chemother. 2002 Feb;46(2):534-7 PubMed

J Clin Microbiol. 1998 Sep;36(9):2759-62 PubMed

Antimicrob Agents Chemother. 2002 Apr;46(4):1098-100 PubMed

J Clin Microbiol. 2000 Dec;38(12):4320-5 PubMed

Diagn Microbiol Infect Dis. 2002 Mar;42(3):217-9 PubMed

Najít záznam

Citační ukazatele

Nahrávání dat ...

Možnosti archivace

Nahrávání dat ...