Mismatch negativity in methamphetamine dependence: a pilot study
Language English Country Poland Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
18389020
DOI
10.55782/ane-2008-1677
PII: 1677
Knihovny.cz E-resources
- MeSH
- Acoustic Stimulation methods MeSH
- Time Factors MeSH
- Adult MeSH
- Electroencephalography methods MeSH
- Contingent Negative Variation physiology MeSH
- Humans MeSH
- Pilot Projects MeSH
- Amphetamine-Related Disorders physiopathology MeSH
- Psychophysics MeSH
- Regression Analysis MeSH
- Evoked Potentials, Auditory physiology MeSH
- Case-Control Studies MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The objective of this study was to verify hypothesised changes in event related potentials (visual mismatch negativity, vMMN) in 17 subjects dependent on methamphetamine (MAMP) compared to age and gender matched 17 healthy volunteers. We found a significant correlation between vMMN and duration of methamphetamine abuse (Spearman correlation coefficient r=0.54-0.78; P<.05). The positive correlation indicates drop of originally more negative response to deviant stimulus, what may indicate a pre-attentive processing enhancement in the first years of MAMP abuse with its decease later on. Accordingly, post-hoc analysis revealed significantly stronger vMMN in patients with length of MAMP abuse shorter than 5 years than in paired controls. There were no such differences in abusers with the length of abuse longer than 5 years. The results show that the visual processing on the pre-attentional level can be influenced by long-term MAMP abuse, what can be specifically assessed by vMMN.
References provided by Crossref.org
Visual mismatch negativity: a predictive coding view
Visual mismatch negativity in the dorsal stream is independent of concurrent visual task difficulty
