Clinical and molecular-genetic markers of ADHD in children
Jazyk angličtina Země Švédsko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
18580852
PII: NEL290308A05
Knihovny.cz E-zdroje
- MeSH
- biologické markery MeSH
- diskriminace (psychologie) fyziologie MeSH
- dítě MeSH
- fenotyp MeSH
- genetické markery MeSH
- genotyp MeSH
- hyperkinetická porucha epidemiologie genetika metabolismus MeSH
- lidé MeSH
- methylfenidát terapeutické užití MeSH
- mladiství MeSH
- neuropsychologické testy MeSH
- polymorfismus genetický genetika MeSH
- pozornost účinky léků fyziologie MeSH
- psychiatrické posuzovací škály MeSH
- psychomotorický výkon účinky léků fyziologie MeSH
- receptory dopaminu D2 genetika MeSH
- stimulanty centrálního nervového systému terapeutické užití MeSH
- vnímání tvaru fyziologie MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika epidemiologie MeSH
- Názvy látek
- biologické markery MeSH
- genetické markery MeSH
- methylfenidát MeSH
- receptory dopaminu D2 MeSH
- stimulanty centrálního nervového systému MeSH
OBJECTIVES: The objective was to make a contribution to deepening the knowledge of the etiopathogenesis of ADHD. DESIGN: In an association study design, an analysis of polymorphisms of selected genes was conducted in 119 hyperkinetic boys and a control group of boys, aged 7-13. Furthermore several psychologically determined subgroups were identified. A connection between psychological functions (endophenotypes) and genes were looked for. RESULTS: There was a statistically significant difference found in allelic and genotype frequencies of the TaqI A polymorphism of the DRD2 gene. The frequency of the allele A1 in hyperkinetic boys and the control subjects was 0.26 and 0.15, respectively (p<0.003). A statistically significant occurrence of atypical genotypes (8/10, 7/10 and 10/11) of the DAT1 gene was also found in hyperkinetic boys and a connection between the M235 polymorphism of the angiotensinogene gene and the positive family history of psychiatric illness was found in probands (p=0.031). Significant correlations between the results of some neuropsychological tests and genes for neuro-/immunomodulators (IL-6, TNF-alpha) and the gene for the brain-derived neurotrophic factor (BDNF) were found. CONCLUSION: The study showed a statistically significant prevalence of A1 allele of the DRD gene in the hyperkinetic group. We also found a significantly higher incidence of atypical DAT genotypes in the hyperkinetic group. Furthermore we found significant connections with particular gene polymorphisms which may hypothetically represent a neurodevelopmental risk factor in the etiopathogenesis of the disorder (IL-2, IL-6, TNF-alpha, BDNF). We further found a connection of the M235 polymorphism of the AGT (angiotensinogene) gene to positive family history of psychiatric illness (p=0.031). As for cognitive characteristics, we identified three subtypes with different cognitive performance profiles. This finding shows interindividual variability of cognitive style in the group of hyperkinetic boys.
