MLXIPL variant in individuals with low and high triglyceridemia in white population in Central Europe
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
Grant support
G0100222
Medical Research Council - United Kingdom
G8802774
Medical Research Council - United Kingdom
R01 AG023522
NIA NIH HHS - United States
R01 AG013196
NIA NIH HHS - United States
RG/07/008/23674
British Heart Foundation - United Kingdom
081081/Z/06/Z
Wellcome Trust - United Kingdom
1R01 AG23522-01
NIA NIH HHS - United States
G19/35
Medical Research Council - United Kingdom
064947/Z/01/Z
Wellcome Trust - United Kingdom
- MeSH
- White People genetics MeSH
- DNA genetics MeSH
- Adult MeSH
- Gene Frequency MeSH
- Genetic Variation MeSH
- Genotype MeSH
- Hypertriglyceridemia blood genetics MeSH
- Polymorphism, Single Nucleotide MeSH
- Middle Aged MeSH
- Humans MeSH
- Base Sequence MeSH
- Aged MeSH
- Case-Control Studies MeSH
- Amino Acid Substitution MeSH
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors genetics MeSH
- Triglycerides blood MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, N.I.H., Extramural MeSH
- Geographicals
- Czech Republic MeSH
- Names of Substances
- DNA MeSH
- MLXIPL protein, human MeSH Browser
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors MeSH
- Triglycerides MeSH
We tested the hypothesis that the MLXIPL rs3812316 variant predicts plasma triglyceride (TG) levels. We compared three groups of adult individuals: 162 persons with TG > 10 mmol/L, 266 persons with TG < 0.65 mmol/L, and 2,043 population-based controls (range of TG concentrations 0.7-8.7 mmol/L). We found a small difference in the frequency of the Gln allele carriers between population controls (20.4%) and persons with low TG (26.3%, P = 0.033). We found no difference between individuals with high TG and population controls, and there was no association between the MLXIPL variant and plasma TG levels among the population controls.
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The Gene Score for Predicting Hypertriglyceridemia: New Insights from a Czech Case-Control Study
