Spatial navigation testing discriminates two types of amnestic mild cognitive impairment
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
19463709
DOI
10.1016/j.bbr.2009.03.041
PII: S0166-4328(09)00205-8
Knihovny.cz E-resources
- MeSH
- Amnesia complications diagnosis MeSH
- Analysis of Variance MeSH
- Hippocampus physiopathology MeSH
- Cognition physiology MeSH
- Cognition Disorders complications diagnosis MeSH
- Middle Aged MeSH
- Humans MeSH
- Neuropsychological Tests MeSH
- Orientation physiology MeSH
- Memory physiology MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Learning physiology MeSH
- Space Perception physiology MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The hippocampus is essential for consolidation of declarative information and spatial navigation. Alzheimer's disease (AD) diagnosis tends to be preceded by a long prodromal period and mild cognitive impairment (MCI). Our goal was to test whether amnestic MCI comprises two different subgroups, with hippocampal and non-hippocampal memory impairment, that vary with respect to spatial navigation ability. A total of 52 patients were classified into two subgroups: non-amnestic MCI (naMCI) (n=10) and amnestic MCI (aMCI) (n=42). The aMCI subgroup was further stratified into memory impairment of hippocampal type-hippocampal aMCI (HaMCI) (n=10) (potential preclinical AD) and isolated retrieval impairment-non-hippocampal (NHaMCI) (n=32). Results were compared to control (n=28) and AD (n=21) groups. We used the Hidden Goal Task, a human analogue of the Morris Water Maze, to examine spatial navigation either dependent (egocentric) or independent of individual's position (allocentric). Overall, the HaMCI group performed poorer on spatial navigation than the NHaMCI group, especially in the latter trials when the HaMCI group exhibited limited capacity to learn and the NHaMCI group exhibited a learning effect. Finally, the HaMCI group performed almost identically as the AD group. Spatial navigation deficit is particularly pronounced in individuals with hippocampus-related memory impairment and may signal preclinical AD.
References provided by Crossref.org
Spatial navigation questionnaires as a supportive diagnostic tool in early Alzheimer's disease
Spatial Navigation and Visuospatial Strategies in Typical and Atypical Aging
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The Combined Effect of APOE and BDNF Val66Met Polymorphisms on Spatial Navigation in Older Adults
Famous landmark identification in amnestic mild cognitive impairment and Alzheimer's disease
Neural correlates of spatial navigation changes in mild cognitive impairment and Alzheimer's disease
Spatial navigation in young versus older adults
Spatial navigation-a unique window into physiological and pathological aging
