Prenatal methamphetamine exposure affects the mesolimbic dopaminergic system and behavior in adult offspring
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
19591914
DOI
10.1016/j.ijdevneu.2009.06.012
PII: S0736-5748(09)00104-X
Knihovny.cz E-resources
- MeSH
- Time MeSH
- Behavior, Animal drug effects physiology MeSH
- Dopamine metabolism MeSH
- Adrenergic Uptake Inhibitors toxicity MeSH
- Rats MeSH
- 3,4-Dihydroxyphenylacetic Acid metabolism MeSH
- Homovanillic Acid metabolism MeSH
- Methamphetamine toxicity MeSH
- Disease Models, Animal MeSH
- Neural Pathways drug effects growth & development physiopathology MeSH
- Nucleus Accumbens drug effects growth & development physiopathology MeSH
- Exploratory Behavior drug effects physiology MeSH
- Motor Activity drug effects physiology MeSH
- Ventral Tegmental Area drug effects growth & development physiopathology MeSH
- Pregnancy MeSH
- Dose-Response Relationship, Drug MeSH
- Prenatal Exposure Delayed Effects metabolism pathology physiopathology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Pregnancy MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Dopamine MeSH
- Adrenergic Uptake Inhibitors MeSH
- 3,4-Dihydroxyphenylacetic Acid MeSH
- Homovanillic Acid MeSH
- Methamphetamine MeSH
Methamphetamine is a commonly abused psychostimulant that causes addiction and is often abused by pregnant women. Acute or chronic administration of methamphetamine elevates the levels of the extracellular monoamine neurotransmitters, such as dopamine. The aim of the present study was to show whether prenatal exposure to methamphetamine (5mg/kg, entire gestation) or saline in Wistar rats induces changes in dopamine levels and its metabolites in the nucleus accumbens, and in behavior (locomotor activity, rearing, and immobility) after the administration of a challenge dose of methamphetamine (1mg/kg) or saline in male offspring. We found that adult offspring prenatally exposed to methamphetamine had higher basal levels of dopamine (about 288%), dihydroxyphenylacetic acid (about 67%) and homovanillic acid (about 74%) in nucleus accumbens. An increased basal level of dopamine corresponds to lower basal immobility in offspring prenatally exposed to methamphetamine. The acute injection of methamphetamine in adulthood increased the level of dopamine in the nucleus accumbens, which is related to an increase of locomotion and rearing (exploration). In addition, prenatally methamphetamine-exposed rats showed higher response to the challenge dose of methamphetamine, when compared to prenatally saline-exposed rats. In conclusion, rats exposed to methamphetamine in utero have shown changes in the mesolimbic dopaminergic system and were more sensitive to the administration of the acute dose of methamphetamine in adulthood.
References provided by Crossref.org
An overview of the methamphetamine effect on male sexual behavior and reproductive system
Can prenatal methamphetamine exposure be considered a good animal model for ADHD?
Perinatal Stress and Methamphetamine Exposure Decreases Anxiety-Like Behavior in Adult Male Rats
The Impact of Neonatal Methamphetamine on Spatial Learning and Memory in Adult Female Rats
Prenatal Exposure to Methamphetamine: Up-Regulation of Brain Receptor Genes
