Treatment of adjuvant-induced arthritis with the combination of methotrexate and probiotic bacteria Escherichia coli O83 (Colinfant)
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- antirevmatika aplikace a dávkování MeSH
- artritida experimentální farmakoterapie imunologie terapie MeSH
- Escherichia coli * fyziologie MeSH
- kombinovaná terapie MeSH
- krysa rodu Rattus MeSH
- lidé MeSH
- methotrexát aplikace a dávkování MeSH
- modely nemocí na zvířatech MeSH
- potkani inbrední LEW MeSH
- probiotika aplikace a dávkování MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- lidé MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antirevmatika MeSH
- methotrexát MeSH
A certain relationship was observed between the gastrointestinal system, arthritis and immune system. Patients with rheumatoid arthritis have an altered microflora composition and disturbed intestinal defensive barrier. Effect of probiotic bacteria (Colinfant; COL) with known favorable effect on intestinal microflora was determined on the methotrexate (MTX) treatment of adjuvant arthritis. Rats with adjuvant arthritis were administered methotrexate 0.5 mg/kg body mass 2-times weekly per os, COL 1 mL/kg body mass every second day per os, and a combination of MTX+COL for a period of 28 d from the immunization. Levels of serum albumin, body mass, changes in hind paw swelling, and arthrogram score were estimated in rats as variables of inflammation and destructive arthritis-associated changes. Treatment with MTX, as well as with the combination treatment with MTX+COL significantly inhibited both inflammation and destructive arthritis-associated changes. The combination treatment inhibited both the hind paw swelling and arthrogram score more remarkably than MTX alone; on the other hand, the difference between combination treatment and MTX alone was not significant. Treatment with COL alone had no effect on adjuvant arthritis in rats. Colinfant can increase the preventive effect of MTX treatment in rat adjuvant arthritis by improving its antiarthritic effects.
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Surgery. 2001 Nov;130(5):859-65 PubMed
Curr Opin Rheumatol. 1991 Jun;3(3):407-20 PubMed
Clin Microbiol Rev. 2003 Oct;16(4):658-72 PubMed
Folia Microbiol (Praha). 2007;52(6):618-26 PubMed
Am J Clin Nutr. 1999 May;69(5):1046S-1051S PubMed
Scand J Rheumatol. 2003;32(4):211-5 PubMed
Am J Clin Nutr. 2001 Feb;73(2 Suppl):444S-450S PubMed
Biol Neonate. 1997;71(4):224-32 PubMed
Mol Immunol. 2008 May;45(9):2690-9 PubMed
Folia Microbiol (Praha). 2006;51(5):478-84 PubMed
Inflammopharmacology. 1997;5(3):219-36 PubMed
Folia Microbiol (Praha). 2007;52(2):189-93 PubMed
Immunol Lett. 2004 May 15;93(2-3):97-108 PubMed
Br J Rheumatol. 1994 Nov;33(11):1030-8 PubMed
Gastroenterology. 1996 Aug;111(2):334-44 PubMed
Int J Immunopharmacol. 1988;10(6):717-28 PubMed
Immunopharmacology. 1988 May-Jun;15(3):133-42 PubMed
Int Arch Allergy Immunol. 2003 Jul;131(3):209-11 PubMed
Aliment Pharmacol Ther. 1997 Dec;11 Suppl 3:17-22; discussion 22-3 PubMed
Br J Rheumatol. 1997 Jan;36(1):64-8 PubMed
Ann N Y Acad Sci. 2005 Jun;1051:570-81 PubMed
Ann Rheum Dis. 2003 May;62(5):423-6 PubMed
J Rheumatol. 1985 Oct;12(5):904-6 PubMed
J Food Prot. 2002 Jan;65(1):153-60 PubMed
J Altern Complement Med. 2002 Feb;8(1):71-5 PubMed
Folia Microbiol (Praha). 2002;47(5):573-8 PubMed
Folia Microbiol (Praha). 2008;53(3):189-94 PubMed
