Characterization of ferritin 2 for the control of tick infestations
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
0757990
Wellcome Trust - United Kingdom
PubMed
20171306
DOI
10.1016/j.vaccine.2010.02.008
PII: S0264-410X(10)00160-X
Knihovny.cz E-zdroje
- MeSH
- Escherichia coli genetika MeSH
- ferritin antagonisté a inhibitory imunologie izolace a purifikace MeSH
- hmyzí proteiny antagonisté a inhibitory imunologie izolace a purifikace MeSH
- infestace klíšťaty prevence a kontrola veterinární MeSH
- klíště imunologie MeSH
- králíci parazitologie MeSH
- nemoci skotu parazitologie prevence a kontrola MeSH
- Rhipicephalus imunologie MeSH
- skot MeSH
- syntetické vakcíny imunologie MeSH
- zvířata MeSH
- Check Tag
- králíci parazitologie MeSH
- skot MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- ferritin MeSH
- hmyzí proteiny MeSH
- syntetické vakcíny MeSH
Ixodes ricinus is one the most abundant tick species in Europe and these ticks transmit pathogens causing human and animal diseases. The cattle ticks, Rhipicephalus (Boophilus) spp., affect cattle production in tropical and subtropical regions of the world. Development of vaccines directed against tick proteins may reduce tick infestations and the transmission of tick-borne pathogens. However, a limiting step in tick vaccine development has been the identification of tick protective antigens. Herein, the tick iron metabolism pathway was targeted in an effort to identify new tick protective antigens. Recombinant I. ricinus (IrFER2) and Rhipicephalus microplus (RmFER2) ferritin 2 proteins were expressed in Escherichia coli and used to immunize rabbits and cattle, respectively. Vaccination with IrFER2 reduced I. ricinus tick numbers, weight and fertility in rabbits with an overall vaccine efficacy (E) of 98%. Control of cattle tick, R. microplus and Rhipicephalus annulatus infestations was obtained in vaccinated cattle with overall E of 64% and 72%, respectively. Notably, the efficacy of the RmFER2 vaccine was similar to that obtained with Bm86 against R. microplus. These collective results demonstrated the feasibility of using ferritin 2 to develop vaccines for the control of tick infestations.
Citace poskytuje Crossref.org
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