Role of efflux in enhancing butanol tolerance of bacteria
Language English Country Netherlands Media print-electronic
Document type Journal Article, Review
PubMed
32553531
DOI
10.1016/j.jbiotec.2020.06.008
PII: S0168-1656(20)30155-3
Knihovny.cz E-resources
- Keywords
- 1-butanol efflux, Butanol toxicity, Efflux pumps,
- MeSH
- Bacterial Proteins MeSH
- Biological Transport MeSH
- Escherichia coli * MeSH
- Membrane Transport Proteins MeSH
- Metabolic Engineering MeSH
- Microbial Viability MeSH
- 1-Butanol * analysis metabolism toxicity MeSH
- Escherichia coli Proteins MeSH
- Pseudomonas putida * MeSH
- Solvents MeSH
- Carrier Proteins MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- AcrAB-TolC protein, E coli MeSH Browser
- Bacterial Proteins MeSH
- Membrane Transport Proteins MeSH
- 1-Butanol * MeSH
- Escherichia coli Proteins MeSH
- Solvents MeSH
- SrpB protein, Pseudomonas putida MeSH Browser
- Carrier Proteins MeSH
N-butanol, a valued solvent and potential fuel extender, could possibly be produced by fermentation using either native producers, i.e. solventogenic Clostridia, or engineered platform organisms such as Escherichia coli or Pseudomonas species, if the main process obstacle, a low final butanol concentration, could be overcome. A low final concentration of butanol is the result of its high toxicity to production cells. Nevertheless, bacteria have developed several mechanisms to cope with this toxicity and one of them is active butanol efflux. This review presents information about a few well characterized butanol efflux pumps from Gram-negative bacteria (P. putida and E. coli) and summarizes knowledge about putative butanol efflux systems in Gram-positive bacteria.
References provided by Crossref.org
