N-butanol, a valued solvent and potential fuel extender, could possibly be produced by fermentation using either native producers, i.e. solventogenic Clostridia, or engineered platform organisms such as Escherichia coli or Pseudomonas species, if the main process obstacle, a low final butanol concentration, could be overcome. A low final concentration of butanol is the result of its high toxicity to production cells. Nevertheless, bacteria have developed several mechanisms to cope with this toxicity and one of them is active butanol efflux. This review presents information about a few well characterized butanol efflux pumps from Gram-negative bacteria (P. putida and E. coli) and summarizes knowledge about putative butanol efflux systems in Gram-positive bacteria.
- MeSH
- bakteriální proteiny MeSH
- biologický transport MeSH
- Escherichia coli * MeSH
- membránové transportní proteiny MeSH
- metabolické inženýrství MeSH
- mikrobiální viabilita MeSH
- n-butanol * analýza metabolismus toxicita MeSH
- proteiny z Escherichia coli MeSH
- Pseudomonas putida * MeSH
- rozpouštědla MeSH
- transportní proteiny MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Toxic alcohols that clinicians commonly encounter are ethylene glycol, methanol, and isopropanol. Adults ingest these either for suicidal intent or to achieve inebriation, since these substances are readily available and cheaper than alcohol. Nevertheless, assorted alcohols are used very often in many applications and any alcohol can be toxic if ingested in large enough quantities. Toxic alcohols discussed here include all saturated aliphatic alcohols containing from 1 to 6 carbons in their molecules.
- Klíčová slova
- isobutanol, sec-butanol, 2-ethylhexanol,
- MeSH
- 1-propanol otrava toxicita MeSH
- 2-propanol otrava toxicita MeSH
- alkoholismus MeSH
- alkoholy * klasifikace otrava toxicita MeSH
- butanoly otrava toxicita MeSH
- ethanol metabolismus otrava toxicita MeSH
- hexanoly otrava toxicita MeSH
- látky znečišťující životní prostředí MeSH
- lidé MeSH
- methanol metabolismus otrava toxicita MeSH
- n-butanol otrava toxicita MeSH
- otrava alkoholem * etiologie metabolismus MeSH
- pentanoly otrava toxicita MeSH
- pití alkoholu metabolismus škodlivé účinky MeSH
- terc-butanol otrava toxicita MeSH
- znečištění životního prostředí MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- práce podpořená grantem MeSH
- přehledy MeSH
