A meeting sponsored by the Bill & Melinda Gates Foundation was held at the Avanti Hotel, Mohammedia, Morocco, July 14-15, 2015. The meeting resulted in the formation of the Cattle Tick Vaccine Consortium (CATVAC).

Animal Disease Research Unit Agricultural Research Service United States Department of Agriculture Washington State University Pullman Washington USA

BIOAGRO DVT Universidade Federal de Viçosa Viçosa MG Brazil

Cattle Fever Tick Research Laboratory Agricultural Research Service United States Department of Agriculture Edinburg TX USA

ClinVet International Bloemfontein South Africa

Council for Scientific and Industrial Research Pretoria Gauteng South Africa

Department of Veterinary Pathobiology Center for Veterinary Health Sciences Oklahoma State University Stillwater OK USA

Facultad de Ciencias Naturales Universidad Autónoma de Querétaro Queretaro Queretaro Mexico

Institute of Parasitology Biology Centre Czech Academy of Sciences Ceske Budejovice Czech Republic

Murdoch University Centre for Comparative Genomics Perth WA Australia

ProtActivity R and D Cuijk The Netherlands

SaBio Instituto de Investigación en Recursos Cinegéticos IREC CSIC UCLM JCCM Ciudad Real Spain

The Genomics Research Institute Department of Genetics Faculty of Natural and Agricultural Sciences University of Pretoria Pretoria South Africa

The University of Queensland Queensland Alliance for Agriculture and Food Innovation St Lucia QLD Australia

Tick Unit International Livestock Research Institute ILRI Nairobi Kenya

Zobrazit více v PubMed

Grace D, Songe M, Knight-Jones T. 21st conference of the World Organisation for Animal Health (OIE) regional commission for Africa. Rabat: ILRI; 2015. Impact of neglected diseases on animal productivity and public health in Africa.

Abbas RZ, Zaman MA, Colwell DD, Gilleard J, Iqbal Z. Acaricide resistance in cattle ticks and approaches to its management: the state of play. Vet Parasitol. 2014;203(1–2):6–20. doi: 10.1016/j.vetpar.2014.03.006. PubMed DOI

Adakal H, Biguezoton A, Zoungrana S, Courtin F, De Clercq EM, Madder M. Alarming spread of the Asian cattle tick Rhipicephalus microplus in West Africa-another three countries are affected: Burkina Faso, Mali and Togo. Exp Appl Acarol. 2013;61(3):383–6. doi: 10.1007/s10493-013-9706-6. PubMed DOI

Allen JR, Humphreys SJ. Immunisation of guinea pigs and cattle against ticks. Nature. 1979;280(5722):491–3. doi: 10.1038/280491a0. PubMed DOI

de la Fuente J, Contreras M. Tick vaccines: current status and future directions. Expert Rev Vaccines. 2015;14(10):1367–76. doi: 10.1586/14760584.2015.1076339. PubMed DOI

de la Fuente J, Almazan C, Canales M, de la Lastra JM P, Kocan KM, Willadsen P. A ten-year review of commercial vaccine performance for control of tick infestations on cattle. Anim Health Res Rev. 2007;8(1):23–8. doi: 10.1017/S1466252307001193. PubMed DOI

Rand KN, Moore T, Sriskantha A, Spring K, Tellam R, Willadsen P, Cobon GS. Cloning and expression of a protective antigen from the cattle tick Boophilus microplus. Proc Natl Acad Sci U S A. 1989;86(24):9657–61. doi: 10.1073/pnas.86.24.9657. PubMed DOI PMC

Miller R, Estrada-Pena A, Almazan C, Allen A, Jory L, Yeater K, Messenger M, Ellis D, de Leon AA P. Exploring the use of an anti-tick vaccine as a tool for the integrated eradication of the cattle fever tick, Rhipicephalus (Boophilus) annulatus. Vaccine. 2012;30(38):5682–7. doi: 10.1016/j.vaccine.2012.05.061. PubMed DOI

Freeman JM, Davey RB, Kappmeyer LS, Kammlah DM, Olafson PU. Bm86 midgut protein sequence variation in South Texas cattle fever ticks. Parasit Vectors. 2010;3:101. doi: 10.1186/1756-3305-3-101. PubMed DOI PMC

Pipano E, Alekceev E, Galker F, Fish L, Samish M, Shkap V. Immunity against Boophilus annulatus induced by the Bm86 (Tick-GARD) vaccine. Exp Appl Acarol. 2003;29(1–2):141–9. doi: 10.1023/A:1024246903197. PubMed DOI

Odongo D, Kamau L, Skilton R, Mwaura S, Nitsch C, Musoke A, Taracha E, Daubenberger C, Bishop R. Vaccination of cattle with TickGARD induces cross-reactive antibodies binding to conserved linear peptides of Bm86 homologues in Boophilus decoloratus. Vaccine. 2007;25(7):1287–96. doi: 10.1016/j.vaccine.2006.09.085. PubMed DOI

Olds C, Mwaura S, Crowder D, Odongo D, van Oers M, Owen J, Bishop R, Daubenberger C. Immunization of cattle with Ra86 impedes Rhipicephalus appendiculatus nymphal-to-adult molting. Ticks Tick Borne Dis. 2012;3(3):170–8. doi: 10.1016/j.ttbdis.2012.03.003. PubMed DOI

Peconick AP, Sossai S, Girao FA, Rodrigues MQ, Souza ESCH, Guzman QF, Patarroyo VA, Vargas MI, Patarroyo JH. Synthetic vaccine (SBm7462) against the cattle tick Rhipicephalus (Boophilus) microplus: preservation of immunogenic determinants in different strains from South America. Exp Parasitol. 2008;119(1):37–43. doi: 10.1016/j.exppara.2007.12.007. PubMed DOI

Hajdusek O, Sojka D, Kopacek P, Buresova V, Franta Z, Sauman I, Winzerling J, Grubhoffer L. Knockdown of proteins involved in iron metabolism limits tick reproduction and development. Proc Natl Acad Sci U S A. 2009;106(4):1033–8. doi: 10.1073/pnas.0807961106. PubMed DOI PMC

Hajdusek O, Almazan C, Loosova G, Villar M, Canales M, Grubhoffer L, Kopacek P, de la Fuente J. Characterization of ferritin 2 for the control of tick infestations. Vaccine. 2010;28(17):2993–8. doi: 10.1016/j.vaccine.2010.02.008. PubMed DOI

Merino O, Antunes S, Mosqueda J, Moreno-Cid JA, de la Lastra JM P, Rosario-Cruz R, Rodriguez S, Domingos A, de la Fuente J. Vaccination with proteins involved in tick-pathogen interactions reduces vector infestations and pathogen infection. Vaccine. 2013;31(49):5889–96. doi: 10.1016/j.vaccine.2013.09.037. PubMed DOI

Lew-Tabor AE, Bruyeres AG, Zhang B, Rodriguez Valle M. Rhipicephalus (Boophilus) microplus tick in vitro feeding methods for functional (dsRNA) and vaccine candidate (antibody) screening. Ticks Tick Borne Dis. 2014;5(5):500–10. doi: 10.1016/j.ttbdis.2014.03.005. PubMed DOI

Louw E, van der Merwe NA, Neitz AW, Maritz-Olivier C. Evolution of the tissue factor pathway inhibitor-like Kunitz domain-containing protein family in Rhipicephalus microplus. Int J Parasitol. 2013;43(1):81–94. doi: 10.1016/j.ijpara.2012.11.006. PubMed DOI

Ali A, Parizi LF, Guizzo MG, Tirloni L, Seixas A, Vaz Ida S, Jr, Termignoni C. Immunoprotective potential of a Rhipicephalus (Boophilus) microplus metalloprotease. Vet Parasitol. 2015;207(1–2):107–14. doi: 10.1016/j.vetpar.2014.11.007. PubMed DOI

Hussein HE, Scoles GA, Ueti MW, Suarez CE, Adham FK, Guerrero FD, Bastos RG. Targeted silencing of the Aquaporin 2 gene of Rhipicephalus (Boophilus) microplus reduces tick fitness. Parasit Vectors. 2015;8:618. doi: 10.1186/s13071-015-1226-2. PubMed DOI PMC

Guerrero FD, Andreotti R, Bendele KG, Cunha RC, Miller RJ, Yeater K, de Leon AA P. Rhipicephalus (Boophilus) microplus aquaporin as an effective vaccine antigen to protect against cattle tick infestations. Parasit Vectors. 2014;7:475. PubMed PMC

Schetters TPM, Jansen T. Vaccine against Rhipicephalus ticks. Edited by WIPO, vol. WO2014154847 A12014. 2014.

Almazan C, Moreno-Cantu O, Moreno-Cid JA, Galindo RC, Canales M, Villar M, de la Fuente J. Control of tick infestations in cattle vaccinated with bacterial membranes containing surface-exposed tick protective antigens. Vaccine. 2012;30(2):265–72. doi: 10.1016/j.vaccine.2011.10.102. PubMed DOI

Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission

Functional Evolution of Subolesin/Akirin

Mining a differential sialotranscriptome of Rhipicephalus microplus guides antigen discovery to formulate a vaccine that reduces tick infestations