Oxime K027: novel low-toxic candidate for the universal reactivator of nerve agent- and pesticide-inhibited acetylcholinesterase
Language English Country England, Great Britain Media print
Document type Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Antidotes pharmacology MeSH
- Chemical Warfare Agents toxicity MeSH
- Cholinesterase Inhibitors toxicity MeSH
- Oximes pharmacology therapeutic use MeSH
- Pesticides toxicity MeSH
- Pyridinium Compounds pharmacology therapeutic use MeSH
- Cholinesterase Reactivators pharmacology MeSH
- Publication type
- Journal Article MeSH
- Evaluation Study MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide MeSH Browser
- Antidotes MeSH
- Chemical Warfare Agents MeSH
- Cholinesterase Inhibitors MeSH
- Oximes MeSH
- Pesticides MeSH
- Pyridinium Compounds MeSH
- Cholinesterase Reactivators MeSH
Oxime K027 is a low-toxic bisquaternary compound originally developed as a reactivator of acetylcholinesterase (AChE) inhibited by nerve agents. The reactivation potency of K027 has been tested as a potential reactivator of AChE inhibited by tabun, sarin, cyclosarin, soman, VX, Russian VX, paraoxon, methylchlorpyrifos, and DDVP. The results show that oxime K027 reactivated AChE inhibited by almost all tested inhibitors to more than 10%, which is believed to be enough for saving the lives of intoxicated organisms. In the case of cyclosarin- and soman-inhibited AChE, oxime K027 did not reach sufficient reactivation potency.
References provided by Crossref.org
Experimental and Established Oximes as Pretreatment before Acute Exposure to Azinphos-Methyl
Combined Pre- and Posttreatment of Paraoxon Exposure
Time-dependent changes of oxime K027 concentrations in different parts of rat central nervous system
