New developments in septic acute kidney injury
Language English Country Czech Republic Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
20533855
DOI
10.33549/physiolres.931936
PII: 931936
Knihovny.cz E-resources
- MeSH
- Acute Kidney Injury etiology MeSH
- Apoptosis MeSH
- Humans MeSH
- Nitric Oxide metabolism MeSH
- Proteomics methods MeSH
- Renal Circulation physiology MeSH
- Shock, Septic etiology MeSH
- Inflammation metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Nitric Oxide MeSH
The kidney is a common "victim organ" of various insults in critically ill patients. Sepsis and septic shock are the dominant causes of acute kidney injury, accounting for nearly 50 % of episodes of acute renal failure. Despite our substantial progress in the understanding of mechanisms involved in septic acute kidney injury there is still a huge pool of questions preclusive of the development of effective therapeutic strategies. This review briefly summarizes our current knowledge of pathophysiological mechanisms of septic acute kidney injury focusing on hemodynamic alterations, peritubular dysfunction, role of inflammatory mediators and nitric oxide, mitochondrial dysfunction and structural changes. Role of proteomics, new promising laboratory method, is mentioned.
References provided by Crossref.org
Searching for mechanisms that matter in early septic acute kidney injury: an experimental study
