Effect of ceramide acyl chain length on skin permeability and thermotropic phase behavior of model stratum corneum lipid membranes
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
21167310
DOI
10.1016/j.bbalip.2010.12.003
PII: S1388-1981(10)00251-9
Knihovny.cz E-zdroje
- MeSH
- antiflogistika nesteroidní farmakologie MeSH
- ceramidy chemie metabolismus MeSH
- chemické modely * MeSH
- indomethacin farmakologie MeSH
- inhibitory fosfodiesteras farmakologie MeSH
- kůže chemie metabolismus MeSH
- lidé MeSH
- permeabilita účinky léků MeSH
- sfingosin chemie metabolismus MeSH
- theofylin farmakologie MeSH
- vysoká teplota MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antiflogistika nesteroidní MeSH
- ceramidy MeSH
- indomethacin MeSH
- inhibitory fosfodiesteras MeSH
- sfingosin MeSH
- theofylin MeSH
Stratum corneum ceramides play an essential role in the barrier properties of skin. However, their structure-activity relationships are poorly understood. We investigated the effects of acyl chain length in the non-hydroxy acyl sphingosine type (NS) ceramides on the skin permeability and their thermotropic phase behavior. Neither the long- to medium-chain ceramides (8-24 C) nor free sphingosine produced any changes of the skin barrier function. In contrast, the short-chain ceramides decreased skin electrical impedance and increased skin permeability for two marker drugs, theophylline and indomethacin, with maxima in the 4-6C acyl ceramides. The thermotropic phase behavior of pure ceramides and model stratum corneum lipid membranes composed of ceramide/lignoceric acid/cholesterol/cholesterol sulfate was studied by differential scanning calorimetry and infrared spectroscopy. Differences in thermotropic phase behavior of these lipids were found: those ceramides that had the greatest impact on the skin barrier properties displayed the lowest phase transitions and formed the least dense model stratum corneum lipid membranes at 32°C. In conclusion, the long hydrophobic chains in the NS-type ceramides are essential for maintaining the skin barrier function. However, this ability is not shared by their short-chain counterparts despite their having the same polar head structure and hydrogen bonding ability.
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