Connectivity between mitochondrial functions and psychiatric disorders
Language English Country Australia Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
- MeSH
- Antidepressive Agents adverse effects pharmacology therapeutic use MeSH
- Antipsychotic Agents adverse effects pharmacology therapeutic use MeSH
- Apoptosis drug effects MeSH
- Models, Biological MeSH
- Mental Disorders drug therapy metabolism MeSH
- Humans MeSH
- DNA, Mitochondrial genetics metabolism MeSH
- Mitochondria genetics metabolism MeSH
- Neuronal Plasticity drug effects MeSH
- Oxidative Stress drug effects MeSH
- Reactive Oxygen Species metabolism MeSH
- Calcium metabolism MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Antidepressive Agents MeSH
- Antipsychotic Agents MeSH
- DNA, Mitochondrial MeSH
- Reactive Oxygen Species MeSH
- Calcium MeSH
Mitochondria provide most of the energy production in cells. They are involved in the regulation of free radicals, calcium buffering, and redox signaling and take part in the intrinsic pathway of apoptosis. Mutations or polymorphisms of mitochondrial DNA, mitochondria-mediated oxidative stress, decrease of adenosine triphosphate production, changes of intracellular calcium and oxidative stress are concerned in various diseases. There is increasing evidence that impaired functions of mitochondria are associated with mood disorders. It is suggested that disturbed energetic metabolism and/or reactive oxygen species production take part in the pathophysiology of mood disorders and could participate in the therapeutic effects or side-effects of antidepressants and mood stabilizers.
References provided by Crossref.org
Effect of Novel Antipsychotics on Energy Metabolism - In Vitro Study in Pig Brain Mitochondria
Control mechanisms in mitochondrial oxidative phosphorylation
