Latent toxoplasmosis reduces gray matter density in schizophrenia but not in controls: voxel-based-morphometry (VBM) study
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Analysis of Variance MeSH
- Adult MeSH
- Enzyme-Linked Immunosorbent Assay MeSH
- Hippocampus microbiology pathology MeSH
- Humans MeSH
- Magnetic Resonance Imaging methods MeSH
- Brain Mapping methods MeSH
- Brain microbiology pathology MeSH
- Cerebral Cortex microbiology pathology MeSH
- Toxoplasmosis, Cerebral complications microbiology pathology MeSH
- Image Processing, Computer-Assisted methods MeSH
- Schizophrenia complications microbiology pathology MeSH
- Temporal Lobe microbiology pathology MeSH
- Thalamus microbiology pathology MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
OBJECTIVES: To address the role of latent T. gondii infection in schizophrenia we studied the influence of latent toxoplasmosis on brain morphology. METHODS: An optimized voxel-based morphometry of magnetic resonance imaging was analyzed by analysis of variance with diagnosis and seropositivity as factors in 44 schizophrenic patients (12 T. gondii positive) and 56 controls (13 T. gondii positive). RESULTS: Grey matter (GM) volume was reduced in schizophrenia patients compared with controls in the cortical regions, hippocampus and in the caudate. In the schizophrenia sample we found a significant reduction of GM volume in T. gondii positive comparing with T. gondii-negative patients bilaterally in the caudate, median cingulate, thalamus and occipital cortex and in the left cerebellar hemispheres. T. gondii-positive and -negative controls did not differ in any cluster. Among participants seropositive to T. gondii the reduction of GM in the schizophrenia subjects was located in the same regions when comparing the entire sample (11,660 over-threshold voxels (P ≤ 0.05, FWR corrected). The differences between T. gondii-negative patients and controls consisted only of 289 voxels in temporal regions. CONCLUSIONS: Our study is the first to document that latent toxoplasmosis reduces GM in schizophrenia but not in controls.
References provided by Crossref.org
Thirty years of studying latent toxoplasmosis: behavioural, physiological, and health insights
The Role of Zebrafish and Laboratory Rodents in Schizophrenia Research
Negative Effects of Latent Toxoplasmosis on Mental Health
Latent toxoplasmosis and olfactory functions of Rh positive and Rh negative subjects
Humans with latent toxoplasmosis display altered reward modulation of cognitive control
Cat scratches, not bites, are associated with unipolar depression--cross-sectional study
