MR spectroscopy as a tool for in vivo determination of steatosis in liver transplant recipients
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
- MeSH
- biopsie MeSH
- deuterium MeSH
- dospělí MeSH
- játra chemie patologie patofyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- lineární modely MeSH
- lipidy biosyntéza MeSH
- magnetická rezonanční spektroskopie metody MeSH
- magnetická rezonanční tomografie metody MeSH
- nelineární dynamika MeSH
- reprodukovatelnost výsledků MeSH
- senioři MeSH
- senzitivita a specificita MeSH
- transplantace jater metody MeSH
- tuková tkáň chemie MeSH
- ztučnělá játra diagnóza metabolismus patologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Názvy látek
- deuterium MeSH
- lipidy MeSH
OBJECT: Among several non-invasive methods of liver fat analysis, the most important role is played by MR imaging and spectroscopy (MRS). This study describes the 1H MRS at 3T measurement of liver fat volume fraction Φ(fat) in a group of liver transplant patients, an at-risk group for the development of de novo steatosis. MATERIALS AND METHODS: Seventy-seven liver transplant recipients who underwent routine protocolar posttransplant examination were divided into three groups: CON-PAT (control group for the cross validation test, 48 patients), PAT-PAT (patients test group for the cross validation test, 29 patients), and PAT (pooled data). Single voxel 1H MRS at 3T was used for the determination of Φ(fat) and histology results (His) were used as the reference standard. RESULTS: Linear and non-linear regression models were used to describe the relationship between Φ(fat) and His. Strong correlation was found for both models with r = 0.83-0.94 (P < 0.001); a higher r was found for non-linear regression in all tested groups. Areas under receiver operation curves were calculated for cut points His ≥ 5 and > 33% and were found in the range of 0.77-0.86. Fibrosis influences the calculation of Φ(fat) and different slopes were obtained for fibrosis stages F0-F1 and F2-F3, respectively. CONCLUSION: Significant correlation was found between the results of histology and 1H MRS measurement of liver fat content. The method is suitable for non-invasive repetitive examination of liver fat in liver-transplants patients between protocol biopsies and for the screening of steatosis in other liver diseases.
Zobrazit více v PubMed
World J Gastroenterol. 2010 Apr 7;16(13):1560-6 PubMed
Hepatology. 2005 Jun;41(6):1313-21 PubMed
Eur Radiol. 2009 Aug;19(8):2033-40 PubMed
J Clin Gastroenterol. 2010 Jan;44(1):58-65 PubMed
Am J Gastroenterol. 2010 Mar;105(3):621-3 PubMed
J Hepatol. 2009 Sep;51(3):433-45 PubMed
AJR Am J Roentgenol. 2008 May;190(5):1331-9 PubMed
Eur J Radiol. 2010 Jun;74(3):e60-6 PubMed
Eur Radiol. 2011 Jan;21(1):87-97 PubMed
Eur Radiol. 2009 Jul;19(7):1786-93 PubMed
J Hepatol. 2009 Aug;51(2):389-97 PubMed
Histopathology. 2006 Nov;49(5):450-65 PubMed
Am J Physiol Endocrinol Metab. 2005 Feb;288(2):E462-8 PubMed
Radiology. 2009 Jan;250(1):95-102 PubMed
Br J Surg. 2010 Sep;97(9):1331-9 PubMed
Hepatology. 2002 Jun;35(6):1485-93 PubMed
Invest Radiol. 1993 Apr;28(4):297-302 PubMed
J Magn Reson Imaging. 2009 Aug;30(2):444-8 PubMed
J Magn Reson Imaging. 1995 May-Jun;5(3):281-5 PubMed
Am J Gastroenterol. 2010 Mar;105(3):613-20 PubMed
Transplantation. 1993 Apr;55(4):807-13 PubMed
Ann Surg. 2007 Jan;245(1):20-30 PubMed
Obesity (Silver Spring). 2010 Apr;18(4):841-7 PubMed
Gastroenterology. 2005 Jun;128(7):1898-906 PubMed
Magn Reson Imaging. 1994;12(3):487-95 PubMed
J Lipid Res. 2004 Jul;45(7):1364-71 PubMed
