Two-dimensional imaging of spontaneous ultra-weak photon emission from the human skin: role of reactive oxygen species
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Diagnostic Imaging methods MeSH
- Adult MeSH
- Electron Spin Resonance Spectroscopy MeSH
- Photometry instrumentation methods MeSH
- Photons * MeSH
- Skin Physiological Phenomena drug effects MeSH
- Head physiology MeSH
- Hydroxyl Radical metabolism MeSH
- Skin drug effects metabolism MeSH
- Humans MeSH
- Oxidative Stress drug effects MeSH
- Hydrogen Peroxide administration & dosage pharmacokinetics pharmacology MeSH
- Reactive Oxygen Species administration & dosage metabolism pharmacology MeSH
- Hand physiology MeSH
- Superoxides metabolism MeSH
- Torso physiology MeSH
- Xanthine administration & dosage pharmacology MeSH
- Xanthine Oxidase administration & dosage pharmacology MeSH
- Iron administration & dosage pharmacology MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Fenton's reagent MeSH Browser
- Hydroxyl Radical MeSH
- Hydrogen Peroxide MeSH
- Reactive Oxygen Species MeSH
- Superoxides MeSH
- Xanthine MeSH
- Xanthine Oxidase MeSH
- Iron MeSH
In the human skin, reactive oxygen species (ROS) produced continuously during oxidative metabolic processes (cellular respiration, oxidative burst) are essential for various cellular processes such as defense against infection, cellular signaling and apoptosis. On the other hand, when the formation of ROS exceeds a capacity of the non-enzymatic and the enzymatic antioxidant defense system, ROS cause the damage to the human skin known to initiate premature skin aging and skin cancer. In this study, two-dimensional spontaneous ultra-weak photon emission from the human skin has been measured using a highly sensitive charged coupled device (CCD) camera. It is demonstrated here that two-dimensional ultra-weak photon emission from the human skin increases with the topical application of exogenous ROS in the following order: hydrogen peroxide (H₂O₂) < superoxide anion radical (O₂•⁻) < hydroxyl radical (HO•). We propose here that the two-dimensional ultra-weak photon emission can be used as a non-invasive tool for the spatial and temporal monitoring of oxidative stress in the human skin.
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