Parasitic fungus Claviceps as a source for biotechnological production of ergot alkaloids
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
22261014
DOI
10.1016/j.biotechadv.2012.01.005
PII: S0734-9750(12)00007-9
Knihovny.cz E-zdroje
- MeSH
- Claviceps genetika metabolismus MeSH
- enzymy metabolismus MeSH
- fermentace MeSH
- genetické inženýrství metody MeSH
- molekulární struktura MeSH
- námelové alkaloidy biosyntéza chemie genetika farmakologie MeSH
- průmyslová mikrobiologie metody MeSH
- žito mikrobiologie MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- enzymy MeSH
- námelové alkaloidy MeSH
Ergot alkaloids produced by the fungus Claviceps parasitizing on cereals, include three major groups: clavine alkaloids, d-lysergic acid and its derivatives and ergopeptines. These alkaloids are important substances for the pharmatech industry, where they are used for production of anti-migraine drugs, uterotonics, prolactin inhibitors, anti-Parkinson agents, etc. Production of ergot alkaloids is based either on traditional field cultivation of ergot-infected rye or on submerged cultures of the fungus in industrial fermentation plants. In 2010, the total production of these alkaloids in the world was about 20,000 kg, of which field cultivation contributed about 50%. This review covers the recent advances in understanding of the genetics and regulation of biosynthesis of ergot alkaloids, focusing on possible applications of the new knowledge to improve the production yield.
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