Parasitic fungus Claviceps as a source for biotechnological production of ergot alkaloids
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
22261014
DOI
10.1016/j.biotechadv.2012.01.005
PII: S0734-9750(12)00007-9
Knihovny.cz E-resources
- MeSH
- Claviceps genetics metabolism MeSH
- Enzymes metabolism MeSH
- Fermentation MeSH
- Genetic Engineering methods MeSH
- Molecular Structure MeSH
- Ergot Alkaloids biosynthesis chemistry genetics pharmacology MeSH
- Industrial Microbiology methods MeSH
- Secale microbiology MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Enzymes MeSH
- Ergot Alkaloids MeSH
Ergot alkaloids produced by the fungus Claviceps parasitizing on cereals, include three major groups: clavine alkaloids, d-lysergic acid and its derivatives and ergopeptines. These alkaloids are important substances for the pharmatech industry, where they are used for production of anti-migraine drugs, uterotonics, prolactin inhibitors, anti-Parkinson agents, etc. Production of ergot alkaloids is based either on traditional field cultivation of ergot-infected rye or on submerged cultures of the fungus in industrial fermentation plants. In 2010, the total production of these alkaloids in the world was about 20,000 kg, of which field cultivation contributed about 50%. This review covers the recent advances in understanding of the genetics and regulation of biosynthesis of ergot alkaloids, focusing on possible applications of the new knowledge to improve the production yield.
References provided by Crossref.org
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