Cryptosporidium tyzzeri and Cryptosporidium muris originated from wild West-European house mice (Mus musculus domesticus) and East-European house mice (Mus musculus musculus) are non-infectious for pigs
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
22465334
DOI
10.1016/j.exppara.2012.03.016
PII: S0014-4894(12)00110-5
Knihovny.cz E-resources
- MeSH
- Cryptosporidium classification genetics physiology MeSH
- Feces parasitology MeSH
- Genotype MeSH
- Host Specificity MeSH
- Cryptosporidiosis parasitology veterinary MeSH
- Mice, SCID MeSH
- Mice parasitology MeSH
- Rodent Diseases parasitology MeSH
- Swine Diseases parasitology MeSH
- Swine MeSH
- DNA, Protozoan chemistry isolation & purification MeSH
- RNA, Ribosomal genetics MeSH
- Sequence Alignment veterinary MeSH
- Animals MeSH
- Check Tag
- Mice parasitology MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic MeSH
- Names of Substances
- DNA, Protozoan MeSH
- RNA, Ribosomal MeSH
Three and 8 week old pigs were inoculated with Cryptosporidium muris HZ206 (Mus musculus musculus isolate), Cryptosporidium tyzerri CR2090 (M. m. musculus isolate) or C. tyzzeri CR4293 (isolate from a hybrid between Mus musculus domesticus and M. m. musculus) at a dose of 1 × 10(7) oocysts per animal. Inoculated pigs showed no detectable infection and no clinical symptoms of cryptosporidiosis during 30 days post infection (DPI), and no macroscopic changes were detected in the digestive tract following necropsy. Developmental stages were not detected in gastrointestinal tract tissue by histology or PCR throughout the duration of the experiment. The infectivity of isolates was verified on SCID mice, in which oocysts shedding started from 4 to 8 DPI. Based on our findings, it can be concluded that pigs are not susceptible to C. muris or C. tyzzeri infection.
References provided by Crossref.org
Diversity of Cryptosporidium spp. in Apodemus spp. in Europe
Cryptosporidium scrofarum n. sp. (Apicomplexa: Cryptosporidiidae) in domestic pigs (Sus scrofa)
