Synergistic effects of dopamine D2-like receptor antagonist sulpiride and β-blocker propranolol on learning in the carousel maze, a dry-land spatial navigation task
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
22525744
DOI
10.1016/j.pbb.2012.04.003
PII: S0091-3057(12)00112-8
Knihovny.cz E-resources
- MeSH
- Dopamine D2 Receptor Antagonists * MeSH
- Dopamine Antagonists administration & dosage MeSH
- Adrenergic beta-Antagonists administration & dosage MeSH
- Maze Learning drug effects physiology MeSH
- Rats MeSH
- Rats, Long-Evans MeSH
- Propranolol administration & dosage MeSH
- Spatial Behavior drug effects physiology MeSH
- Psychomotor Performance drug effects physiology MeSH
- Receptors, Dopamine D2 physiology MeSH
- Sulpiride administration & dosage MeSH
- Drug Synergism MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Dopamine D2 Receptor Antagonists * MeSH
- Dopamine Antagonists MeSH
- Adrenergic beta-Antagonists MeSH
- Propranolol MeSH
- Receptors, Dopamine D2 MeSH
- Sulpiride MeSH
Spatial navigation attracts the attention of neuroscientists as an animal analogue of human declarative memory. The Carousel maze is a dry-land navigational paradigm, which proved to be useful in studying neurobiological substrates of learning. The task involves avoidance of a stable sector on a rotating arena and is highly dependent upon the hippocampus. The present study aims at testing hypothesis that sulpiride (a centrally-active dopamine D2-like receptor antagonist) and propranolol (a beta-blocker) impair spatial learning in the Carousel maze after combined systemic administration. These doses were previously shown to be subthreshold in this task. Results showed that both substances affected behavior and significantly potentiated their negative effects on spatial learning. This suggests central interaction of both types of receptors in influencing acquisition of this dynamic-environment task.
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