Ochratoxin A exposure biomarkers in the Czech Republic and comparison with foreign countries
Language English Country England, Great Britain Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Carcinogens metabolism pharmacokinetics toxicity MeSH
- Food Contamination MeSH
- Kidney drug effects MeSH
- Humans MeSH
- Milk, Human metabolism MeSH
- Kidney Diseases etiology MeSH
- Ochratoxins metabolism pharmacokinetics toxicity MeSH
- Tissue Distribution MeSH
- Environmental Exposure MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Geographicals
- Czech Republic MeSH
- Names of Substances
- Carcinogens MeSH
- ochratoxin A MeSH Browser
- Ochratoxins MeSH
Among ochratoxins, ochratoxin A (OTA) occupies a dominant place and represents significant risk for human and animal health which also implies economic losses around the world. OTA is nephrotoxic, hepatotoxic, teratogenic and immunotoxic mycotoxin. OTA exposure may lead to formation of DNA adducts resulting to genotoxicity and carcinogenicity (human carcinogen of 2B group). Now it seems that OTA could be "a complete carcinogen" which obliges to monitor its presence in biological materials, especially using the suitable biomarkers. In this article, OTA findings in urine, blood, serum, plasma and human kidneys (target dose) in the Czech Republic and comparison with foreign countries are presented.
References provided by Crossref.org
Ochratoxin A: 50 Years of Research
Producers and important dietary sources of ochratoxin A and citrinin
