Thermoresponsive nanoparticles based on poly(2-alkyl-2-oxazolines) and Pluronic F127
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Isotope Labeling MeSH
- Calorimetry MeSH
- Micelles MeSH
- Neoplasms diagnostic imaging MeSH
- Nanoparticles chemistry MeSH
- Oxazoles chemistry MeSH
- Poloxamer chemistry MeSH
- Radionuclide Imaging MeSH
- Iodine Radioisotopes chemistry MeSH
- Transition Temperature MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Micelles MeSH
- Oxazoles MeSH
- Poloxamer MeSH
- poly(2-oxazoline) MeSH Browser
- Iodine Radioisotopes MeSH
We synthesized statistical poly(2-isopropyl-2-oxazoline-co-2-butyl-2-oxazolines) (POXs) that are molecularly dissolved below their cloud point temperature in aqueous milieu and are incorporated into micellar nanoparticles of biocompatible Pluronic F127 (F127) after heating their solution above transition temperature, T(tr). A functional comonomer 2-(but-3-enyl)-2-oxazoline copolymerized into one of the POXs (polymer E) allows introduction of fenolic moieties and subsequent radionuclide labeling with iodine-125. Self-assembly of the polymer E with F127 leads to formation of radioactive nanoparticles with hydrodynamic diameter 20 nm in aqueous solution by heating to 37 °C. The nanoparticles are intended to be used as radioimaging tool in solid tumor diagnostics.
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