Inhibition and induction of glutathione S-transferases by flavonoids: possible pharmacological and toxicological consequences
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
- MeSH
- Antioxidants adverse effects metabolism therapeutic use MeSH
- Biotransformation MeSH
- Enzyme Induction MeSH
- Flavonoids adverse effects metabolism therapeutic use MeSH
- Glutathione Transferase antagonists & inhibitors biosynthesis chemistry metabolism MeSH
- Enzyme Inhibitors adverse effects metabolism therapeutic use MeSH
- Food-Drug Interactions MeSH
- Liver drug effects enzymology metabolism MeSH
- Humans MeSH
- Dietary Supplements * adverse effects MeSH
- Xenobiotics pharmacokinetics MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Antioxidants MeSH
- Flavonoids MeSH
- Glutathione Transferase MeSH
- Enzyme Inhibitors MeSH
- Xenobiotics MeSH
Many studies reviewed herein demonstrated the potency of some flavonoids to modulate the activity and/or expression of glutathione S-transferases (GSTs). Because GSTs play a crucial role in the detoxification of xenobiotics, their inhibition or induction may significantly affect metabolism and biological effects of many drugs, industrials, and environmental contaminants. The effect of flavonoids on GSTs strongly depends on flavonoid structure, concentration, period of administration, as well as on GST isoform and origin. Moreover, the results obtained in vitro are often contrary to the vivo results. Based on these facts, the revelation of important flavonoid-drug or flavonoid-pollutant interaction has been complicated. However, it should be borne in mind that ingestion of certain flavonoids in combination with drugs or pollutants (e.g., acetaminophen, simvastatin, cyclophosphamide, cisplatine, polycyclic aromatic hydrocarbons, chlorpyrifos, acrylamide, and isocyanates), which are GST substrates, could have significant pharmacological and toxicological consequences. Although reasonable consumptions of a flavonoids-rich diet (that may lead to GST induction) are mostly beneficial, the uncontrolled intake of high concentrations of certain flavonoids (e.g., quercetin and catechins) in dietary supplements (that may cause GST inhibition) may threaten human health.
References provided by Crossref.org
Age-related changes in hepatic activity and expression of detoxification enzymes in male rats
