Plasma fatty acid composition in patients with pancreatic cancer: correlations to clinical parameters
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Cholesterol blood MeSH
- Phospholipids blood MeSH
- Incidence MeSH
- 8,11,14-Eicosatrienoic Acid blood MeSH
- alpha-Linolenic Acid blood MeSH
- Docosahexaenoic Acids blood MeSH
- Middle Aged MeSH
- Humans MeSH
- Fatty Acids blood MeSH
- Lipid Metabolism MeSH
- Pancreatic Neoplasms epidemiology MeSH
- Nutritional Status MeSH
- Malnutrition epidemiology MeSH
- Aged MeSH
- Case-Control Studies MeSH
- Triglycerides blood MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic epidemiology MeSH
- Names of Substances
- Cholesterol MeSH
- Phospholipids MeSH
- 8,11,14-Eicosatrienoic Acid MeSH
- alpha-Linolenic Acid MeSH
- Docosahexaenoic Acids MeSH
- Fatty Acids MeSH
- Triglycerides MeSH
Pancreatic cancer (PC) ranks as the fourth cause of cancer-related deaths in the Czech Republic. Evidence exists that deregulation of fatty acid (FA) metabolism is connected with some malignancies; therefore, we decided to analyze FA profile in plasma lipid classes in patients with PC with relation to tumor staging, nutritional status, and survival. The study included 84 patients (47 males, 37 females) with PC and 68 controls (36 males, 32 females). FA patterns were analyzed in plasma lipid classes by gas-chromatography. We observed increased proportion of total monounsaturated FA (MUFA) in PC group in all plasma lipid classes. These changes were connected with increased Δ9-desaturase (SCD1) and Δ5-desaturase indices. Correlations of dihomo-γ-linolenic acid (DHGLA) with these variables were opposite. Longer survival of patients was connected with higher content of EPA, DHA, and with lower SCD1 index, respectively. Plasma phospholipid proportions of α-linolenic acid, DHGLA, EPA, and n-3 polyunsaturated fatty acids displayed negative trend with tumor staging. Plasma lipid FA pattern in PC patients resulted from decreased dietary fat intake and increased de novo synthesis of FA with transformation into MUFA. Changes in FA profile implicated some pathophysiological mechanisms responsible for disturbed FA metabolism in PC and importance of appropriate nutritional support.
References provided by Crossref.org
