Membrane cholesterol is essential for cell membrane properties, just as serum cholesterol is important for the transport of molecules between organs. This review focuses on cholesterol transport between lipoproteins and lipid rafts on the surface of macrophages. Recent studies exploring this mechanism and recognition of the central dogma-the key role of macrophages in cardiovascular disease-have led to the notion that this transport mechanism plays a major role in the pathogenesis of atherosclerosis. The exact molecular mechanism of this transport remains unclear. Future research will improve our understanding of the molecular and cellular bases of lipid raft-associated cholesterol transport.

Department of Anesthesia and Intensive Medicine 1st Faculty of Medicine Charles University and University Military Hospital 128 08 Prague Czech Republic

Department of Physiology Faculty of Science Charles University 128 44 Prague Czech Republic

Faculty of Veterinary Medicine University of Veterinary Sciences Brno Small Animal Clinic 612 00 Brno Czech Republic

Laboratory for Atherosclerosis Research Centre for Experimental Medicine Institute for Clinical and Experimental Medicine 140 21 Prague Czech Republic

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