Implantation of left ventricular assist device complicated by undiagnosed thrombophilia
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu kazuistiky, časopisecké články
PubMed
23109751
PubMed Central
PMC3461681
Knihovny.cz E-zdroje
- Klíčová slova
- Anticoagulants/therapeutic use, blood coagulation disorders/complications, factor V Leiden, factor V/genetics, left ventricular assist device, perioperative care, postoperative complications, thrombophilia/genetics, thrombus/etiology/prevention & control,
- MeSH
- barevná dopplerovská echokardiografie MeSH
- dilatační kardiomyopatie komplikace patofyziologie MeSH
- echokardiografie transezofageální MeSH
- faktor V genetika MeSH
- fatální výsledek MeSH
- funkce levé komory srdeční * MeSH
- genetická predispozice k nemoci MeSH
- genetické testování metody MeSH
- infekce spojené s protézou etiologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- methylentetrahydrofolátreduktasa (NADPH2) genetika MeSH
- mutace MeSH
- mutační analýza DNA MeSH
- nedostatek proteinu S komplikace diagnóza genetika MeSH
- nemoci srdce krev diagnostické zobrazování etiologie genetika MeSH
- podpůrné srdeční systémy škodlivé účinky MeSH
- prediktivní hodnota testů MeSH
- protézy - design MeSH
- pulzní dopplerovská echokardiografie MeSH
- srdeční selhání diagnostické zobrazování etiologie patofyziologie terapie MeSH
- tepový objem MeSH
- trombofilie krev komplikace diagnóza genetika MeSH
- trombóza krev diagnostické zobrazování etiologie genetika MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- Názvy látek
- factor V Leiden MeSH Prohlížeč
- faktor V MeSH
- methylentetrahydrofolátreduktasa (NADPH2) MeSH
- MTHFR protein, human MeSH Prohlížeč
A patient with dilated cardiomyopathy and no history of thromboembolic events received a surgically implanted axial-flow left ventricular assist device. After implantation, transesophageal echocardiography revealed a giant thrombus on the lateral and anterior aspects of the left ventricle. The inflow cannula inserted through the apex of the left ventricle was not obstructed, and the device generated satisfactory blood flow. Laboratory screening for thrombophilia showed protein S deficiency, heterozygous factor V Leiden mutation, and heterozygous MTHFR C667T mutation. During the entire duration of circulatory support, no significant suction events were detected, and the patient was listed for heart transplantation. Ventricular assist device implantation can unmask previously undiagnosed thrombophilia; therefore, it should be necessary to identify thrombophilic patients before cardiac support implantation.
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