The oxidized low-density lipoprotein/β2-glycoprotein I complex is associated with abdominal obesity in healthy middle-aged men
Jazyk angličtina Země Švýcarsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
23171597
DOI
10.1159/000343049
PII: 000343049
Knihovny.cz E-zdroje
- MeSH
- abdominální obezita krev patofyziologie MeSH
- ateroskleróza krev patofyziologie MeSH
- beta-2-glykoprotein I krev MeSH
- biologické markery krev MeSH
- dospělí MeSH
- inhibitor aktivátoru plazminogenu 1 krev MeSH
- interleukin-8 krev MeSH
- intimomediální šíře tepenné stěny MeSH
- inzulinová rezistence MeSH
- lidé středního věku MeSH
- lidé MeSH
- lipoproteiny LDL krev MeSH
- multivariační analýza MeSH
- obvod pasu MeSH
- oxidační stres MeSH
- produkty pokročilé oxidace proteinů krev MeSH
- regresní analýza MeSH
- studie případů a kontrol MeSH
- thioredoxiny krev MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- beta-2-glykoprotein I MeSH
- biologické markery MeSH
- inhibitor aktivátoru plazminogenu 1 MeSH
- interleukin-8 MeSH
- lipoproteiny LDL MeSH
- oxidized low density lipoprotein MeSH Prohlížeč
- produkty pokročilé oxidace proteinů MeSH
- SERPINE1 protein, human MeSH Prohlížeč
- thioredoxiny MeSH
BACKGROUND/AIMS: Oxidized low-density lipoprotein (oxLDL) in complex with β2-glycoprotein I (β2GPI) has been associated with autoimmune diseases, diabetes mellitus, chronic renal disease and coronary atherosclerosis. The aim of our study was to determine whether plasma levels of oxLDL/β2GPI complexes are associated with insulin resistance, inflammation and markers of endothelial damage in obese middle-aged men and, if so, whether oxLDL/β2GPI correlates better with insulin resistance parameters than oxLDL, advanced oxidation protein products (AOPP) or thioredoxin. METHODS: A total of 72 healthy men were recruited (41 obese and 31 nonobese individuals). Waist circumference >94 cm was used as the criterion for abdominal obesity. RESULTS: The obese men demonstrated higher oxLDL/β2GPI levels (p < 0.001), homeostasis model assessment of insulin resistance (p < 0.01) and intima-media thickness of the common carotid artery (p < 0.01). oxLDL/β2GPI correlated with more insulin resistance parameters compared to AOPP, thioredoxin or oxLDL. Furthermore, oxLDL/β2GPI was associated with plasminogen activator inhibitor-I (PAI-I; r = 0.365, p < 0.001) and negatively with interleukin-8 (r = -0.297, p < 0.05). CONCLUSIONS: In summary, oxLDL/β2GPI reflects the criterion for abdominal obesity and markers of insulin resistance in our study. The independent positive correlation with PAI-I indicates that oxLDL/β2GPI may serve as an early marker of low-grade inflammation and atherosclerosis initiation.
Citace poskytuje Crossref.org
Serum oxLDL-β2GPI complex reflects metabolic syndrome and inflammation in adipose tissue in obese
