The oxidized low-density lipoprotein/β2-glycoprotein I complex is associated with abdominal obesity in healthy middle-aged men
Language English Country Switzerland Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
23171597
DOI
10.1159/000343049
PII: 000343049
Knihovny.cz E-resources
- MeSH
- Obesity, Abdominal blood physiopathology MeSH
- Atherosclerosis blood physiopathology MeSH
- beta 2-Glycoprotein I blood MeSH
- Biomarkers blood MeSH
- Adult MeSH
- Plasminogen Activator Inhibitor 1 blood MeSH
- Interleukin-8 blood MeSH
- Carotid Intima-Media Thickness MeSH
- Insulin Resistance MeSH
- Middle Aged MeSH
- Humans MeSH
- Lipoproteins, LDL blood MeSH
- Multivariate Analysis MeSH
- Waist Circumference MeSH
- Oxidative Stress MeSH
- Advanced Oxidation Protein Products blood MeSH
- Regression Analysis MeSH
- Case-Control Studies MeSH
- Thioredoxins blood MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- beta 2-Glycoprotein I MeSH
- Biomarkers MeSH
- Plasminogen Activator Inhibitor 1 MeSH
- Interleukin-8 MeSH
- Lipoproteins, LDL MeSH
- oxidized low density lipoprotein MeSH Browser
- Advanced Oxidation Protein Products MeSH
- SERPINE1 protein, human MeSH Browser
- Thioredoxins MeSH
BACKGROUND/AIMS: Oxidized low-density lipoprotein (oxLDL) in complex with β2-glycoprotein I (β2GPI) has been associated with autoimmune diseases, diabetes mellitus, chronic renal disease and coronary atherosclerosis. The aim of our study was to determine whether plasma levels of oxLDL/β2GPI complexes are associated with insulin resistance, inflammation and markers of endothelial damage in obese middle-aged men and, if so, whether oxLDL/β2GPI correlates better with insulin resistance parameters than oxLDL, advanced oxidation protein products (AOPP) or thioredoxin. METHODS: A total of 72 healthy men were recruited (41 obese and 31 nonobese individuals). Waist circumference >94 cm was used as the criterion for abdominal obesity. RESULTS: The obese men demonstrated higher oxLDL/β2GPI levels (p < 0.001), homeostasis model assessment of insulin resistance (p < 0.01) and intima-media thickness of the common carotid artery (p < 0.01). oxLDL/β2GPI correlated with more insulin resistance parameters compared to AOPP, thioredoxin or oxLDL. Furthermore, oxLDL/β2GPI was associated with plasminogen activator inhibitor-I (PAI-I; r = 0.365, p < 0.001) and negatively with interleukin-8 (r = -0.297, p < 0.05). CONCLUSIONS: In summary, oxLDL/β2GPI reflects the criterion for abdominal obesity and markers of insulin resistance in our study. The independent positive correlation with PAI-I indicates that oxLDL/β2GPI may serve as an early marker of low-grade inflammation and atherosclerosis initiation.
References provided by Crossref.org
Serum oxLDL-β2GPI complex reflects metabolic syndrome and inflammation in adipose tissue in obese
