Cholesterol metabolism in acute upper gastrointestinal bleeding, preliminary observations
Language English Country Austria Media print-electronic
Document type Journal Article
- MeSH
- Acute Disease MeSH
- Cholesterol blood MeSH
- Esophageal and Gastric Varices blood etiology therapy MeSH
- Endoscopy, Gastrointestinal MeSH
- Gastrointestinal Hemorrhage blood etiology therapy MeSH
- Cholesterol, HDL blood MeSH
- Hematemesis blood therapy MeSH
- Hemodilution adverse effects MeSH
- Hypercholesterolemia blood MeSH
- Proton Pump Inhibitors administration & dosage MeSH
- Infusions, Intravenous MeSH
- Liver Cirrhosis blood complications therapy MeSH
- Intensive Care Units MeSH
- Cohort Studies MeSH
- Combined Modality Therapy MeSH
- Cholesterol, LDL blood MeSH
- Middle Aged MeSH
- Humans MeSH
- Lypressin administration & dosage analogs & derivatives MeSH
- Melena blood therapy MeSH
- Follow-Up Studies MeSH
- Omeprazole administration & dosage MeSH
- Parenteral Nutrition, Total MeSH
- Aged MeSH
- Fluid Therapy MeSH
- Terlipressin MeSH
- Erythrocyte Transfusion MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Cholesterol MeSH
- Cholesterol, HDL MeSH
- Proton Pump Inhibitors MeSH
- Cholesterol, LDL MeSH
- Lypressin MeSH
- Omeprazole MeSH
- Terlipressin MeSH
Hypocholesterolemia is commonly found in critically ill patients; however, the aetiology of this condition remains unclear. Several clinical studies refer to the possible negative impact of haemodilution on cholesterol (CH) metabolism in acute medical conditions. The aim of this study was to examine the serum CH profile (total CH, LDL and HDL CH) during acute gastrointestinal bleeding which is a life-threatening condition characterised by alterations in lipid metabolism. Serum non-CH sterols (lathosterol, squalene, sitosterol and campesterol) concentrations as markers of CH synthesis and CH absorption were measured at the same time. Twenty-four patients with acute upper gastrointestinal bleeding (UGIB) were measured for these parameters over a 6-day period. The control group was 100 healthy blood donors.We found lower plasma levels of total CH (p < 0.001) and LDL CH (p < 0.05) in patients with UGIB than in the control group. The decreased HDL CH plasma levels in patients were not statistically significant. In addition, patients had significantly lower plasma levels of lathosterol, squalene, campesterol and sitosterol (p < 0.05).Our results showed abnormalities not only in the CH plasma profile, but also in plasma concentrations of non-CH sterols. These findings of alterations in both the CH synthesis and absorption process could be a contributory cause of hypocholesterolemia during acute gastrointestinal bleeding. However, further research is necessary.
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