MicroRNAs involved in chemo- and radioresistance of high-grade gliomas
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
- MeSH
- apoptóza MeSH
- ATM protein MeSH
- checkpoint kinasa 2 MeSH
- chemorezistence genetika MeSH
- DNA vazebné proteiny metabolismus MeSH
- fosfatidylinositol-3-kinasy metabolismus MeSH
- gliom * farmakoterapie genetika radioterapie MeSH
- invazivní růst nádoru MeSH
- lidé MeSH
- mikro RNA genetika metabolismus MeSH
- nádorové supresorové proteiny metabolismus MeSH
- nádorový supresorový protein p53 metabolismus MeSH
- nádory mozku farmakoterapie genetika radioterapie MeSH
- protein-serin-threoninkinasy metabolismus MeSH
- proteiny buněčného cyklu metabolismus MeSH
- protoonkogenní proteiny c-akt metabolismus MeSH
- tolerance záření genetika MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- ATM protein, human MeSH Prohlížeč
- ATM protein MeSH
- checkpoint kinasa 2 MeSH
- CHEK2 protein, human MeSH Prohlížeč
- DNA vazebné proteiny MeSH
- mikro RNA MeSH
- nádorové supresorové proteiny MeSH
- nádorový supresorový protein p53 MeSH
- protein-serin-threoninkinasy MeSH
- proteiny buněčného cyklu MeSH
- protoonkogenní proteiny c-akt MeSH
- TP53 protein, human MeSH Prohlížeč
High-grade gliomas (HGGs) are malignant primary brain tumors of glial cell origin. Despite optimal course of treatment, including maximal surgical resection followed by adjuvant chemo- and/or radiotherapy, the prognosis still remains poor. The main reason is the commonly occurring chemo- and radioresistance of these tumors. In recent years, several signaling pathways, especially PI3K/AKT and ATM/CHK2/p53, have been linked to the resistance of gliomas. Moreover, additional studies have shown that these pathways are significantly regulated by microRNAs (miRNAs), short endogenous RNA molecules that modulate gene expression and control many biological processes including apoptosis, proliferation, cell cycle, invasivity, and angiogenesis. MiRNAs are not only highly deregulated in gliomas, their expression signatures have also been shown to predict prognosis and therapy response. Therefore, they present promising biomarkers and therapeutic targets that might overcome the resistance to treatment and improve prognosis of glioma patients. In this review, we summarize the current knowledge of the functional role of miRNAs in gliomas resistance to chemo- and radiotherapy.
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