Pneumococcal urinary antigen positivity in healthy colonized children: is it age dependent?
Jazyk angličtina Země Rakousko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- antigeny bakteriální moč MeSH
- dítě MeSH
- lidé MeSH
- nazofarynx imunologie mikrobiologie MeSH
- počet mikrobiálních kolonií statistika a číselné údaje MeSH
- předškolní dítě MeSH
- referenční hodnoty MeSH
- reprodukovatelnost výsledků MeSH
- senzitivita a specificita MeSH
- stárnutí imunologie MeSH
- Streptococcus pneumoniae imunologie izolace a purifikace MeSH
- věkové rozložení MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika epidemiologie MeSH
- Názvy látek
- antigeny bakteriální MeSH
BACKGROUND: Pneumococcal urinary antigen test is a valuable tool for diagnosing pneumococcal pneumonia and meningitis in adults. Its use in children is generally not accepted because of nonspecificity at this age. It is frequently positive in asymptomatic nasopharyngeal carriers. The aim of our study was to assess the age limit from which the test is no longer positive in asymptomatic healthy carriers. METHODS: A total of 197 children aged 36-83 months attending 9 day care centers in Prague were enrolled during February and March 2010. Nasopharyngeal swab specimens were collected from each participant and selectively cultivated. The presence of pneumococcal antigen in urine was detected by BinaxNOW® S. pneumoniae kit. RESULTS: Streptococcus pneumoniae was cultivated in 53.3 % of healthy children with the highest colonization rate (59.3 %) in children aged 48-59 months. The most frequently colonizing serotypes were: 19F, 23F, 3, 19A, 6B and 4. The presence of pneumococcal antigen in urine decreased with age from 39.0 % in 36-47 months to 17.9 % in 72-83 months old (p = 0.031). The antigen positivity was serotype-dependent and more frequent in nonvaccinated children. CONCLUSION: We demonstrated age-dependent linear decrease of pneumococcal antigen excretion into urine in healthy children. The positivity rate of the test in children aged 72-83 months was similar to that referred in healthy adults, irrespective of colonization. To confirm this age limit for use of this test in diagnostics of pneumococcal diseases, further study in school-age children is justified.
Zobrazit více v PubMed
J Clin Microbiol. 2003 Jul;41(7):2810-3 PubMed
J Clin Microbiol. 1993 Aug;31(8):2097-100 PubMed
Clin Infect Dis. 2001 Mar 1;32(5):824-5 PubMed
J Antimicrob Chemother. 2002 Dec;50 Suppl S2:59-73 PubMed
J Infect. 1991 Sep;23(2):109-16 PubMed
Chest. 2001 Jan;119(1):243-9 PubMed
J Clin Microbiol. 2004 Jun;42(6):2518-22 PubMed
J Exp Med. 1917 Oct 1;26(4):477-93 PubMed
J Gen Intern Med. 1991 May-Jun;6(3):189-98 PubMed
J Infect Dis. 1980 Dec;142(6):923-33 PubMed
Proc Soc Exp Biol Med. 1979 Nov;162(2):249-53 PubMed
Eur Respir J. 2003 Feb;21(2):209-14 PubMed
Epidemiol Infect. 2006 Dec;134(6):1179-87 PubMed
Ann Emerg Med. 1996 Jun;27(6):721-5 PubMed
J Clin Microbiol. 2009 Apr;47(4):1046-9 PubMed
Am J Med. 1983 Jul 28;75(1B):85-92 PubMed
Pediatr Infect Dis J. 2003 Jul;22(7):589-92 PubMed
Biochemistry. 1980 Sep 30;19(20):4712-9 PubMed
Int J Pediatr Otorhinolaryngol. 1999 Oct 5;49 Suppl 1:S151-3 PubMed
Clin Infect Dis. 2002 Apr 1;34(7):1025-8 PubMed
Int J Antimicrob Agents. 2008 Jan;31(1):3-11 PubMed
J Clin Microbiol. 2008 Jan;46(1):225-34 PubMed
Semin Respir Crit Care Med. 2005 Dec;26(6):563-74 PubMed
Pediatr Infect Dis J. 2003 Mar;22(3):262-8 PubMed
Chest. 2001 Jan;119(1):9-11 PubMed
J Clin Microbiol. 2004 Aug;42(8):3620-5 PubMed
Clin Infect Dis. 2005 Oct 15;41(8):1209-10 PubMed
Scand J Infect Dis. 2006;38(3):166-71 PubMed
J Clin Microbiol. 2003 May;41(5):2161-3 PubMed
