Relevance of infection with human papillomavirus: the role of the p53 tumor suppressor protein and E6/E7 zinc finger proteins (Review)
Language English Country Greece Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
24045364
DOI
10.3892/ijo.2013.2105
Knihovny.cz E-resources
- MeSH
- Papillomavirus Infections metabolism pathology MeSH
- Humans MeSH
- Metallothionein metabolism MeSH
- Cell Transformation, Neoplastic MeSH
- Tumor Suppressor Protein p53 metabolism MeSH
- Uterine Cervical Neoplasms virology MeSH
- Head and Neck Neoplasms classification virology MeSH
- Oncogene Proteins, Viral metabolism MeSH
- Papillomaviridae metabolism MeSH
- Papillomavirus E7 Proteins metabolism MeSH
- Repressor Proteins metabolism MeSH
- Protein-Tyrosine Kinases metabolism MeSH
- Zinc Fingers MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- E6 protein, Human papillomavirus type 16 MeSH Browser
- Metallothionein MeSH
- Tumor Suppressor Protein p53 MeSH
- oncogene protein E7, Human papillomavirus type 16 MeSH Browser
- Oncogene Proteins, Viral MeSH
- Papillomavirus E7 Proteins MeSH
- Repressor Proteins MeSH
- Protein-Tyrosine Kinases MeSH
Human papillomaviruses (HPV) are small circular, double-stranded DNA viruses infecting epithelial tissues. HPV types can be classified both as high-risk or low-risk. Of the more than 120 different identified types of HPV, the majority are involved in infections of the genital tract, cancer of the cervix, vulva, vagina and penis, and of non-anogenital localizations, such as the head and neck areas. From the point of view of the infection, human papillomaviruses have developed several molecular mechanisms to enable infected cells to suppress apoptosis. This review provides a comprehensive and critical summary of the current literature that focuses on cervical carcinoma and cancer of the head and neck caused by HPV. In particular, we discuss HPV virology, the molecular mechanisms of carcinogenesis, the role of the tumor suppressor protein p53 and the E6/E7 zinc finger proteins. Classification of HPV according to diagnosis is also described.
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