Repetitive transcranial magnetic stimulation reduces cigarette consumption in schizophrenia patients
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
PubMed
24211840
DOI
10.1016/j.pnpbp.2013.10.019
PII: S0278-5846(13)00241-8
Knihovny.cz E-resources
- Keywords
- ANOVA, CDSS, Calgary Depression Scale for schizophrenia, Consumption, DLPFC, Dorsolateral prefrontal cortex, EEG, EMG, ICD-10, International Classification of Diseases, revision 10, MADRS, MINI, MT, Mini-International Neuropsychiatric Interview, Montgomery and Asberg Depression Scale, PANSS, Positive and Negative Syndrome Scale, Schizophrenia, Smoking, Stimulation, analysis of variance, dorsolateral prefrontal cortex, electroencephalography, electromyography, motor threshold, rTMS, repetitive transcranial magnetic stimulation,
- MeSH
- Adult MeSH
- Double-Blind Method MeSH
- Smoking psychology therapy MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Smoking Cessation methods MeSH
- Prefrontal Cortex physiology MeSH
- Smoking Prevention * MeSH
- Schizophrenic Psychology * MeSH
- Transcranial Magnetic Stimulation * MeSH
- Symptom Assessment MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Randomized Controlled Trial MeSH
INTRODUCTION: High-frequency repetitive transcranial magnetic stimulation (rTMS) over the left dorsolateral prefrontal cortex (DLPFC) seemed to decrease tobacco consumption and craving in nicotine-dependent people without psychiatric disorder or otherwise healthy people. Even if the prevalence of cigarette smoking in schizophrenia patients is high and estimated to be between 45% and 88%, this technique has not been systematically studied in this indication in schizophrenia yet. THE AIM OF THE STUDY: The aim of this study was to test the ability of high-frequency (10Hz) rTMS over the left DLPFC to decrease cigarette consumption in schizophrenia patients. METHODS: The study included 35 male schizophrenia patients on stable antipsychotic medication. The patients were divided into two groups: the first (18 patients) were actively stimulated and the second (17 patients) underwent sham (placebo) stimulation. The sham rTMS was administered using a purpose-built sham coil that was identical in appearance to the real coil and made the same noise but did not deliver a substantial stimulus. The rTMS was administered at the stimulation parameters: location (left dorsolateral prefrontal cortex: DLPFC), intensity of magnetic stimulation in % of motor threshold (110%), stimulation frequency (10Hz), number of trains (20), single train duration (10s), inter-train interval (30s), and total number of stimulation sessions (21). In each stimulation session, 2000TMSpulses were given, with a total of 42,000pulses per treatment course. Patients noted the number of cigarettes smoked in the 7days before treatment, during the whole stimulation treatment (21days), and again for a 7-day period after treatment. RESULTS: Cigarette consumption was statistically significantly lower in the actively stimulated patients than in the sham rTMS group as early as the first week of stimulation. No statistically relevant correlations were found in the changes of ongoing negative or depressive schizophrenia symptoms and the number of cigarettes smoked. CONCLUSION: High-frequency rTMS over the left DLPFC has the ability to decrease the number of cigarettes smoked in schizophrenia patients.
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