A novel biomarker-based approach for the detection of asymptomatic brain injury during catheter ablation of atrial fibrillation
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
24238018
DOI
10.1111/jce.12325
Knihovny.cz E-zdroje
- Klíčová slova
- S100B, atrial fibrillation, catheter ablation, magnetic resonance imaging, stroke,
- MeSH
- biologické markery analýza MeSH
- cévní mozková příhoda diagnóza etiologie MeSH
- fibrilace síní komplikace chirurgie MeSH
- incidence MeSH
- katetrizační ablace škodlivé účinky MeSH
- lidé středního věku MeSH
- lidé MeSH
- magnetická rezonanční tomografie MeSH
- pooperační komplikace diagnóza epidemiologie MeSH
- poranění mozku diagnóza epidemiologie etiologie MeSH
- rizikové faktory MeSH
- S-100 kalcium vázající protein G, podjednotka beta analýza MeSH
- senioři MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- biologické markery MeSH
- S-100 kalcium vázající protein G, podjednotka beta MeSH
- S100B protein, human MeSH Prohlížeč
BACKGROUND: Diffusion-weighted magnetic resonance imaging (DW-MRI) is a widely used method for studying of asymptomatic brain injury during catheter ablation of atrial fibrillation (AF). However, this technique lacks sensitivity for subtle or diffuse brain lesions. We investigated whether detection of the ablation-related brain injury can improve by assessment of a biomarker of brain damage-protein S100B. METHODS AND RESULTS: DW-MRI and assessment of S100B were performed in 58 patients undergoing radiofrequency catheter ablation of paroxysmal or persistent AF 1 day before and after the procedure. We observed no symptomatic neurological complications. S100B levels increased after ablation above the upper reference limit of 105 ng/L in 3 patients. One of them developed a new ischemic lesion on the DW-MRI. No acute lesions emerged on DW-MRI in the patients with normal postablation S100B levels. CONCLUSION: Serial assessment of serum protein S100B may improve detection of asymptomatic acute brain injury in patients undergoing radiofrequency catheter ablation of AF. In our study, the incidence of these events was 1.7% when evaluated only by DW-MRI, but the incidence increased to 5% after employing the more sensitive biomarker-based approach.
Department of Biochemistry Institute for Clinical and Experimental Medicine Prague Czech Republic
Department of Radiology Institute for Clinical and Experimental Medicine Prague Czech Republic
Department of Radiology Na Homolce Hospital Prague Czech Republic
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