A novel biomarker-based approach for the detection of asymptomatic brain injury during catheter ablation of atrial fibrillation
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24238018
DOI
10.1111/jce.12325
Knihovny.cz E-resources
- Keywords
- S100B, atrial fibrillation, catheter ablation, magnetic resonance imaging, stroke,
- MeSH
- Biomarkers analysis MeSH
- Stroke diagnosis etiology MeSH
- Atrial Fibrillation complications surgery MeSH
- Incidence MeSH
- Catheter Ablation adverse effects MeSH
- Middle Aged MeSH
- Humans MeSH
- Magnetic Resonance Imaging MeSH
- Postoperative Complications diagnosis epidemiology MeSH
- Brain Injuries diagnosis epidemiology etiology MeSH
- Risk Factors MeSH
- S100 Calcium Binding Protein beta Subunit analysis MeSH
- Aged MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biomarkers MeSH
- S100 Calcium Binding Protein beta Subunit MeSH
- S100B protein, human MeSH Browser
BACKGROUND: Diffusion-weighted magnetic resonance imaging (DW-MRI) is a widely used method for studying of asymptomatic brain injury during catheter ablation of atrial fibrillation (AF). However, this technique lacks sensitivity for subtle or diffuse brain lesions. We investigated whether detection of the ablation-related brain injury can improve by assessment of a biomarker of brain damage-protein S100B. METHODS AND RESULTS: DW-MRI and assessment of S100B were performed in 58 patients undergoing radiofrequency catheter ablation of paroxysmal or persistent AF 1 day before and after the procedure. We observed no symptomatic neurological complications. S100B levels increased after ablation above the upper reference limit of 105 ng/L in 3 patients. One of them developed a new ischemic lesion on the DW-MRI. No acute lesions emerged on DW-MRI in the patients with normal postablation S100B levels. CONCLUSION: Serial assessment of serum protein S100B may improve detection of asymptomatic acute brain injury in patients undergoing radiofrequency catheter ablation of AF. In our study, the incidence of these events was 1.7% when evaluated only by DW-MRI, but the incidence increased to 5% after employing the more sensitive biomarker-based approach.
Department of Biochemistry Institute for Clinical and Experimental Medicine Prague Czech Republic
Department of Radiology Institute for Clinical and Experimental Medicine Prague Czech Republic
Department of Radiology Na Homolce Hospital Prague Czech Republic
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