Effect of zearalenone on reproductive parameters and expression of selected testicular genes in mice
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
24412631
DOI
10.1016/j.reprotox.2014.01.003
PII: S0890-6238(14)00004-5
Knihovny.cz E-resources
- Keywords
- Fertility, Gene expression, Reproductive parameters in male mice, Spermatogenesis, Zearalenone, qPCR,
- MeSH
- Apoptosis drug effects MeSH
- Gene Expression drug effects MeSH
- Mice MeSH
- Estrogens, Non-Steroidal toxicity MeSH
- Spermatogenesis drug effects MeSH
- Spermatozoa drug effects pathology MeSH
- Testis drug effects metabolism MeSH
- Zearalenone toxicity MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Estrogens, Non-Steroidal MeSH
- Zearalenone MeSH
We tested the effect of two different concentrations (150μg/l and 0.15μg/l) of mycotoxin zearalenone (ZEA) on the reproductive parameters and expression of testicular genes in male mice. In adult males, no reduction of body or reproductive organ weight was observed, and the seminiferous tubules were morphologically normal with ongoing spermatogenesis. However, we found decreased sperm concentration, increase of morphologically abnormal spermatozoa and increased binding of apoptotic marker annexin V. This study was also focused on the evaluation of gene expression profiles of 28 genes playing important roles during the processes occurring in the testicular tissue. We detected changes in the expression of genes important for proper spermatogenesis. Surprisingly, we observed a stronger effect after exposure to the lower dose of ZEA.
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