Both genetic and dietary factors underlie individual differences in DNA damage levels and DNA repair capacity
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
24674629
DOI
10.1016/j.dnarep.2014.01.016
PII: S1568-7864(14)00027-5
Knihovny.cz E-zdroje
- Klíčová slova
- DNA damage, DNA repair capacity, Diet, Genetic polymorphisms, Molecular epidemiology study,
- MeSH
- antioxidancia metabolismus MeSH
- DNA vazebné proteiny genetika metabolismus MeSH
- dospělí MeSH
- endonukleasy genetika metabolismus MeSH
- genetická variace MeSH
- genetické markery MeSH
- interakce genů a prostředí MeSH
- jaderné proteiny genetika metabolismus MeSH
- jednonukleotidový polymorfismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- oprava DNA * MeSH
- poškození DNA genetika MeSH
- senioři MeSH
- sexuální faktory MeSH
- stravovací zvyklosti * MeSH
- transkripční faktory genetika metabolismus MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Norsko MeSH
- Názvy látek
- antioxidancia MeSH
- DNA excision repair protein ERCC-5 MeSH Prohlížeč
- DNA vazebné proteiny MeSH
- endonukleasy MeSH
- genetické markery MeSH
- jaderné proteiny MeSH
- transkripční faktory MeSH
The interplay between dietary habits and individual genetic make-up is assumed to influence risk of cancer, via modulation of DNA integrity. Our aim was to characterize internal and external factors that underlie inter-individual variability in DNA damage and repair and to identify dietary habits beneficial for maintaining DNA integrity. Habitual diet was estimated in 340 healthy individuals using a food frequency questionnaire and biomarkers of antioxidant status were quantified in fasting blood samples. Markers of DNA integrity were represented by DNA strand breaks, oxidized purines, oxidized pyrimidines and a sum of all three as total DNA damage. DNA repair was characterized by genetic variants and functional activities of base and nucleotide excision repair pathways. Sex, fruit-based food consumption and XPG genotype were factors significantly associated with the level of DNA damage. DNA damage was higher in women (p=0.035). Fruit consumption was negatively associated with the number of all measured DNA lesions, and this effect was mediated mostly by β-cryptoxanthin and β-tocopherol (p<0.05). XPG 1104His homozygotes appeared more vulnerable to DNA damage accumulation (p=0.001). Sex and individual antioxidants were also associated with DNA repair capacity; both the base and nucleotide excision repairs were lower in women and the latter increased with higher plasma levels of ascorbic acid and α-carotene (p<0.05). We have determined genetic and dietary factors that modulate DNA integrity. We propose that the positive health effect of fruit intake is partially mediated via DNA damage suppression and a simultaneous increase in DNA repair capacity.
Citace poskytuje Crossref.org
A pooled analysis of host factors that affect nucleotide excision repair in humans
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