Comparison of the effect of stem cell therapy and percutaneous transluminal angioplasty on diabetic foot disease in patients with critical limb ischemia
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu klinické zkoušky, časopisecké články, multicentrická studie, práce podpořená grantem
PubMed
25304666
DOI
10.1016/j.jcyt.2014.08.010
PII: S1465-3249(14)00742-7
Knihovny.cz E-zdroje
- Klíčová slova
- critical limb ischemia, percutaneous transluminal angioplasty, stem cell therapy,
- MeSH
- angioplastika * MeSH
- autologní štěp MeSH
- buněčná a tkáňová terapie MeSH
- diabetická noha patologie patofyziologie chirurgie MeSH
- lidé středního věku MeSH
- lidé MeSH
- onemocnění periferních arterií patologie patofyziologie chirurgie MeSH
- senioři MeSH
- transplantace kmenových buněk * MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
BACKGROUND AIMS: The aim of our study was to compare the effect of autologous stem cell therapy (SCT) and percutaneous transluminal angioplasty (PTA) on diabetic foot disease (DFD) in patients with critical limb ischemia (CLI). METHODS: Thirty-one patients with DFD and CLI treated by autologous stem cells and 30 patients treated by PTA were included in the study; 23 patients with the same inclusion criteria who could not undergo PTA or SCT formed the control group. Amputation-free survival, transcutaneous oxygen pressure (TcPO2) and wound healing were assessed over 12 months. RESULTS: Amputation-free survival after 6 and 12 months was significantly greater in the SCT and PTA groups compared with controls (P = 0.001 and P = 0.0029, respectively) without significant differences between the active treatment groups. Increase in TcPO2 did not differ between SCT and PTA groups until 12 months (both Ps < 0.05 compared with baseline), whereas TcPO2 in the control group did not change over the follow-up period. More healed ulcers were observed up to 12 months in the SCT group compared with the PTA and control groups (84 versus 57.7 versus 44.4 %; P = 0.042). CONCLUSIONS: Our study showed comparable effects of SCT and PTA on CLI, a major amputation rate that was superior to conservative therapy in patients with diabetic foot and an observable effect of SCT on wound healing. Our results support SCT as a potential promising treatment in patients with CLI and diabetic foot.
Institute for Clinical and Experimental Medicine Prague Czech Republic
Institute of Experimental Medicine Czech Academy of Science Prague Czech Republic
Citace poskytuje Crossref.org
The Use of Autologous Cell Therapy in Diabetic Patients with Chronic Limb-Threatening Ischemia
