Perspective taking abilities in amnestic mild cognitive impairment and Alzheimer's disease
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25541035
DOI
10.1016/j.bbr.2014.12.033
PII: S0166-4328(14)00829-8
Knihovny.cz E-resources
- Keywords
- Alzheimer's disease, Mild cognitive impairment, Perspective taking task, Spatial transformation, Standardized Road-Map Test of Direction Sense,
- MeSH
- Alzheimer Disease psychology MeSH
- Amnesia psychology MeSH
- Cognition * MeSH
- Cognitive Dysfunction psychology MeSH
- Humans MeSH
- Neuropsychological Tests MeSH
- Task Performance and Analysis MeSH
- Cross-Sectional Studies MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Aging psychology MeSH
- Case-Control Studies MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Perspective taking is the ability to imagine what a scene looks like from a different viewpoint, which has been reported to be impaired in Alzheimer's disease (AD). This study compared overhead and first-person view perspective taking abilities in patients with mild cognitive impairment (MCI) and AD. A newly developed Arena Perspective Taking Task (APTT), using an environment of a circular arena, was used to compare 23 AD patients and 38 amnestic MCI patients with 18 healthy controls. The results were contrasted with a published perspective taking test (Standardized Road-Map Test of Direction Sense, RMTDS). The AD group was impaired in both overhead and first-person view APTT versions, but the impairment in the overhead view version applied specifically to women. Patients with aMCI were impaired in the first-person view but not in the overhead view version. Substantial sexual differences were found in the overhead but not in the first-person view APTT version. The RMTDS resembled both APTT versions: patients with aMCI were impaired in this test and also women in both patient groups were less accurate than men. Using the receiver operating characteristic analysis, the highest predictive power for MCI and AD patients diagnosis versus controls was observed for their success rate in the first-person view version. The results suggest distinction between overhead and first-person view perspective taking in the impairment of aMCI patients and the sex differences. The first-person view perspective taking is a potentially important candidate psychological marker for AD.
References provided by Crossref.org
Spatial perspective taking is impaired in spinocerebellar ataxias and Friedreich ataxia
Spatial Navigation and Visuospatial Strategies in Typical and Atypical Aging
