Viscoelastic and mechanical properties of hyaluronan films and hydrogels modified by carbodiimide
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25563954
DOI
10.1016/j.carbpol.2014.11.049
PII: S0144-8617(14)01162-X
Knihovny.cz E-resources
- Keywords
- Carbodiimide, Hyaluronan, Mechanical properties, Modification, Viscoelastic properties,
- MeSH
- Ethyldimethylaminopropyl Carbodiimide chemistry MeSH
- Hydrogels chemistry MeSH
- Hyaluronic Acid chemistry MeSH
- Tensile Strength MeSH
- Proton Magnetic Resonance Spectroscopy MeSH
- Elasticity * MeSH
- Spectroscopy, Fourier Transform Infrared MeSH
- Succinimides chemistry MeSH
- Viscosity MeSH
- Water MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Ethyldimethylaminopropyl Carbodiimide MeSH
- Hydrogels MeSH
- Hyaluronic Acid MeSH
- N-hydroxysuccinimide MeSH Browser
- Succinimides MeSH
- Water MeSH
This study investigated an effect of different ways of the preparation of insoluble hyaluronan material on its mechanical and viscoelastic properties. Hyaluronan (NaHy) of molecular weight Mw=500,000 g mol(-1) was modified with N-(3-dimethylaminopropyl-N'-ethylcarbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS), to be able absorb liquid without changing its mechanical properties. The modified, water insoluble NaHy materials were prepared in different geometry; as modified films and modified cylinders with exact dimensions. The occurrence of modification was confirmed by FT-IR (Fourier transform infrared spectroscopy) and (1)H NMR (proton nuclear magnetic resonance) spectroscopy and swelling test. The determined mechanical and viscoelastic properties of unmodified and modified hyaluronan revealed the high dependency of elasticity changes depending on the gel processing method. Moreover, NaHy gels in the cylindrical form with the sponge-like structure predominant them as a convenient geometry for application in a humid environment.
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