Viscoelastic and mechanical properties of hyaluronan films and hydrogels modified by carbodiimide
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
25563954
DOI
10.1016/j.carbpol.2014.11.049
PII: S0144-8617(14)01162-X
Knihovny.cz E-zdroje
- Klíčová slova
- Carbodiimide, Hyaluronan, Mechanical properties, Modification, Viscoelastic properties,
- MeSH
- ethyldimethylaminopropylkarbodiimid chemie MeSH
- hydrogely chemie MeSH
- kyselina hyaluronová chemie MeSH
- pevnost v tahu MeSH
- protonová magnetická rezonanční spektroskopie MeSH
- pružnost * MeSH
- spektroskopie infračervená s Fourierovou transformací MeSH
- sukcinimidy chemie MeSH
- viskozita MeSH
- voda MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- ethyldimethylaminopropylkarbodiimid MeSH
- hydrogely MeSH
- kyselina hyaluronová MeSH
- N-hydroxysuccinimide MeSH Prohlížeč
- sukcinimidy MeSH
- voda MeSH
This study investigated an effect of different ways of the preparation of insoluble hyaluronan material on its mechanical and viscoelastic properties. Hyaluronan (NaHy) of molecular weight Mw=500,000 g mol(-1) was modified with N-(3-dimethylaminopropyl-N'-ethylcarbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS), to be able absorb liquid without changing its mechanical properties. The modified, water insoluble NaHy materials were prepared in different geometry; as modified films and modified cylinders with exact dimensions. The occurrence of modification was confirmed by FT-IR (Fourier transform infrared spectroscopy) and (1)H NMR (proton nuclear magnetic resonance) spectroscopy and swelling test. The determined mechanical and viscoelastic properties of unmodified and modified hyaluronan revealed the high dependency of elasticity changes depending on the gel processing method. Moreover, NaHy gels in the cylindrical form with the sponge-like structure predominant them as a convenient geometry for application in a humid environment.
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