Macrophage subsets in the adipose tissue could be modified by sex and the reproductive age of women
Language English Country Ireland Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
25795161
DOI
10.1016/j.atherosclerosis.2015.03.018
PII: S0021-9150(15)00178-1
Knihovny.cz E-resources
- Keywords
- Adipose tissue, Monocytes/macrophages, Reproductive status, Sex,
- MeSH
- Biomarkers analysis MeSH
- Health Status Disparities * MeSH
- Adult MeSH
- GPI-Linked Proteins analysis MeSH
- Middle Aged MeSH
- Humans MeSH
- Lipopolysaccharide Receptors analysis MeSH
- Macrophages immunology MeSH
- Postmenopause MeSH
- Premenopause MeSH
- Receptors, IgG analysis MeSH
- Risk Factors MeSH
- Reproduction * MeSH
- Aged MeSH
- Sex Factors MeSH
- Aging immunology MeSH
- Adipose Tissue immunology MeSH
- Age Factors MeSH
- Inflammation immunology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Biomarkers MeSH
- FCGR3B protein, human MeSH Browser
- GPI-Linked Proteins MeSH
- Lipopolysaccharide Receptors MeSH
- Receptors, IgG MeSH
The presence of proinflammatory monocytes/macrophages (CD14+CD16+) has been documented in conditions of inflammation, such as atherosclerosis. We analysed the proportion of proinflammatory monocytes/macrophages in perirenal and perivascular fat in healthy living kidney donors with regard to sex and age reflecting reproductive status in women; therefore, women were further divided to younger and older group (younger and older than 51 years) reflecting potential age of menopause. Monocyte/macrophages were identified as CD14+ mononuclear cells and divided into subpopulations based on the co-expression of CD16. We found no differences in the monocyte/macrophage content between men (n = 15) and women (n = 28). Conversely, we observed a higher proportion of double positive CD14+CD16+ monocytes/macrophages in older women (n = 14) compared to younger women (n = 14). In addition, a strong correlation was found between the monocyte/macrophage content in fat and age only in older women. Therefore, proinflammatory monocytes/macrophages (CD14+CD16+) should be evaluated according to the sex and age.
Transplant Surgery Department Institute for Clinical and Experimental Medicine Prague Czech Republic
References provided by Crossref.org
Rapid Drop in Coronary Heart Disease Mortality in Czech Male Population-What Was Actually behind It?
The relationship between non-HDL cholesterol and macrophage phenotypes in human adipose tissue
